Results 51 to 60 of about 6,117,968 (304)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
, 2018 Concept and story by Francisco De La Mora & Ernesto Priego Art by Cristina Durán La Grúa EstudioDesign by Daniela ...
de la Mora, Francisco +5 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Hybrid Power Sharing: On How to Stabilize the Political Situation in Multi-segmental Societies
Politeja, 2018 There are various ways of reducing conflicts and of stabilizing the political situation in states where society is made up of many different ethnic groups and religious communities, and where relations between these segments – or between them and the ...
Krzysztof Trzciński
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Leveraging the power of the sharing economy
, 2020 Humans, by nature, are a sharing bunch. Compared to most other species in the animal kingdom, humans are willing to share resources, with much of that sharing governed by a range of social norms and principles of equity (Hamann et al., 2011).
Brodie, R, Northey, G
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
EnergiesThis paper presents a two-level hierarchical control method for the power distribution between the hybrid energy storage system (HESS) and the main dc bus of a microgrid for ultrafast charging of electric vehicles (EVs).
Alexandra Blanch-Fortuna +5 more
doaj +1 more source
Applied Sciences, 2018 A drive system with an open-end winding permanent magnet synchronous motor (OW-PMSM) fed by a dual inverter and powered by two independent power sources is suitable for electric vehicles.
Yi-Fan Jia +5 more
doaj +1 more source