Results 61 to 70 of about 2,204,074 (292)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Power Sharing and Voltage Vector Distribution Model of a Dual Inverter Open-End Winding Motor Drive System for Electric Vehicles

Applied Sciences, 2018
A drive system with an open-end winding permanent magnet synchronous motor (OW-PMSM) fed by a dual inverter and powered by two independent power sources is suitable for electric vehicles.
Yi-Fan Jia, Liang Chu, Nan Xu, Yu-Kuan Li, Di Zhao, Xin Tang   +5 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Hierarchical Control of Power Distribution in the Hybrid Energy Storage System of an Ultrafast Charging Station for Electric Vehicles

Energies
This paper presents a two-level hierarchical control method for the power distribution between the hybrid energy storage system (HESS) and the main dc bus of a microgrid for ultrafast charging of electric vehicles (EVs).
Alexandra Blanch-Fortuna, David Zambrano-Prada, Oswaldo López-Santos, Abdelali El Aroudi, Luis Vázquez-Seisdedos, Luis Martinez-Salamero   +5 more
doaj   +1 more source

For What it’s Worth: The Political Construction of Quality in French and Italian Wine Markets

, 2017
At the heart of political organization, we find weak and atomized individuals who aggregate their power to challenge concentrated power. Wine politics show us that within market economies we find the same political movements.
Carter, E.
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Practical Intersubjectivity and Normative Guidance: Bratman on Shared Agency

Journal of Social Ontology, 2014
In an important new book on shared agency, Michael Bratman develops an account of the normative demand for the coordination of intentions amongst participants in shared agency. Bratman seeks to understand this form of normative guidance in terms of that
Abraham Sesshu Roth
doaj  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

An Improved Droop Control Method for Voltage-Source Inverter Parallel Systems Considering Line Impedance Differences

Energies, 2019
In this paper, the effect of the line impedance difference between various inverters on power sharing with the traditional droop control method is fully analyzed. It reveals that the line impedance difference causes a significant reactive power error. An
Junjie Ma, Xudong Wang, Jinfeng Liu, Hanying Gao   +3 more
doaj   +1 more source