Results 1 to 10 of about 144,951 (303)

On the power spectral density applied to the analysis of old canvases [PDF]

open access: yesSignal Processing, 2018
A routine task for art historians is painting diagnostics, such as dating or attribution. Signal processing of the X-ray image of a canvas provides useful information about its fabric. However, previous methods may fail when very old and deteriorated artworks or simply canvases of small size are studied.
Francisco J. Simois   +1 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Numerical Optimization and Cyber-Physical- Social Computing for Vibrations of the Elliptical Treadmill Based on GSO-BPNN Model

open access: yesIEEE Access, 2018
The finite element method was used to compute the vibration characteristics of the elliptical treadmill, and the computational results were then compared with those of the experimental test to verify its correctness.
Bo Liang, Taotao Zhang
doaj   +1 more source

Testing Equality of Multiple Power Spectral Density Matrices [PDF]

open access: yesIEEE Transactions on Signal Processing, 2018
This work was partly supported by the Spanish MINECO grants COMONSENS Network (TEC2015-69648-REDC) and KERMES Network (TEC2016-81900-REDT/AEI); by the Spanish MINECO and the European Commission (ERDF) grants ADVENTURE (TEC2015-69868-C2-1- R), WINTER (TEC2016-76409-C2-2-R), CARMEN (TEC2016-75067-C4-4- R) and CAIMAN (TEC2017-86921-C2-1-R and TEC2017 ...
David Ramírez 0001   +4 more
openaire   +5 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Asymptotically-unbiased nonparametric estimation of the power spectral density from uniformly-spaced data with missing samples [PDF]

open access: yesAdvances in Statistical Climatology, Meteorology and Oceanography
The nonparametric estimation of the power spectral density of uniformly-spaced data with missing samples is revisited. Classical estimators, such as the standard periodogram and the Lomb-Scargle periodogram, are biased when samples are missing.
C. Chavanne
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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