Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu +17 more
wiley +1 more source
Voltage abnormity prediction method of lithium-ion energy storage power station using informer based on Bayesian optimization. [PDF]
Rao Z, Wu J, Li G, Wang H.
europepmc +1 more source
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou +14 more
wiley +1 more source
Comparative analysis of public concerns regarding treated water discharged from the Fukushima Daiichi Nuclear Power Station: perspectives before and after the initial release. [PDF]
Liu M +5 more
europepmc +1 more source
Factors affecting anxiety among administrative officers working within the urgent protective action planning zone of a nuclear power station. [PDF]
Hori H +5 more
europepmc +1 more source
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
From carbon neutral to carbon negative: a theoretical bioenergy and CO<sub>2</sub> removal retrofit at Ngāwhā geothermal power station. [PDF]
Titus K, Dempsey D, Peer R, Hanik F.
europepmc +1 more source
Reconstruction of residents' thyroid equivalent doses from internal radionuclides after the Fukushima Daiichi nuclear power station accident. [PDF]
Ohba T +5 more
europepmc +1 more source
Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu +13 more
wiley +1 more source

