Results 41 to 50 of about 21,448,207 (249)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A control engineering approach to the assessment of supply chain resilience [PDF]

, 2012
This is an Author's Accepted Manuscript of an article published in International Journal of Production Research, 50(21), 6162 - 6187, 2012 [copyright Taylor & Francis], available online at: http://www.tandfonline.com/10.1080/00207543.2012.710764.There is
Naim, M.M., Spiegler, Virginia,, Spiegler, VLM, Wikner, J, Wikner, Joakim, Naim, Mohamed Mohamed, Spiegler, Virginia L M,, Naim, MM, Naim, Mohamed M,, Spiegler, Virginia L. M., Spiegler, V.L.M., Wikner, Joakim,, Wikner, J., Naim, Mohammed,   +13 more
core   +1 more source

The power to prioritize the health system resilience agenda: A review of global strategies and guidelines

SSM - Health Systems
Power is infrequently explored in health system resilience, yet is integral to understand the choices made that shape what is prioritized and funded for resilience, which actors are given responsibility for resilience, and which health system capacities ...
Celia Blaas, Mariano Salazar, Dell D. Saulnier   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

A Resilience Toolbox and Research Design for Black Sky Hazards to Power Grids

Complexity, 2019
A structured collection of tools for engineering resilience and a research approach to improve the resilience of a power grid are described in this paper.
Dmitry Borisoglebsky, Liz Varga
doaj   +1 more source

A review of key strategies in realizing power system resilience

Global Energy Interconnection, 2018
The world is witnessing increasing frequency of extreme events. The power system is the backbone critical infrastructure of our economy and is under treat of such events.
Yanling Lin, Zhaohong Bie, Aici Qiu
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Robustness-Driven Resilience Evaluation of Self-Adaptive Software Systems [PDF]

, 2015
An increasingly important requirement for certain classes of software-intensive systems is the ability to self-adapt their structure and behavior at run-time when reacting to changes that may occur to the system, its environment, or its goals.
de Lemos, Rogerio, Cámara, Javier, Ventura, Rafael, Laranjeiro, Nuno, Vieira, Marco   +4 more
core   +1 more source

A review of resilience enhancement strategies in renewable power system under HILP events

Energy Reports, 2023
With the increasing attention to residential and industrial electricity reliability, resilience recovery of smart grids under extreme events, such as intentional attacks and natural calamities, has been considered a crucial technology.
Yihao Xu, Yankai Xing, Qihua Huang, Jian Li, Guangdou Zhang, Olusola Bamisile, Qi Huang   +6 more
doaj   +1 more source