Results 51 to 60 of about 21,448,207 (249)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Examining Power System Resilience From the Perspective of Consumers: A Review

IEEE Access
This paper presents a comprehensive review of power system resilience through the lens of power consumers. As consumers play a pivotal role within the power system by being end users and ultimate cost-bearers, understanding how consumers perceive and ...
Saranga K. Abeygunawardane, Visvakumar Aravinthan, Xiaoheng Wang, Anil Pahwa, Chanan Singh   +4 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

How resilient is a power system? An open-source tool integrating GIS and Optimal Power Flow for resilience assessment

Energy Nexus
The concept of resilience has gained prominence across diverse fields and has recently emerged as a crucial concept in power systems, complementing traditional notions of reliability, robustness, and security.
Montserrat Montalà-Palau, Marc Cheah Mañé, Oriol Gomis-Bellmunt   +2 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Impact of wind power on the unit commitment, operating reserves and market design [PDF]

, 2011
Paper presented at the 2011 IEEE Power and Energy Society General Meeting, San Diego, CA, 24-29 July 2011This article highlights and demonstrates the new requirements variable and partly unpredictable wind power will bring to unit commitment and power ...
Milligan, M., Lange, B., Gibescu, M., Michael Milligan, Hannele Holttinen, Lange, Bernard, Kiviluoma, K., Juha Kiviluoma, Meibom, P., Meibom, Peter, O\u27Malley, Mark, Peter Meibom, Madeleine Gibescu, Kiviluoma, Juha; id_orcid, Tuohy, Aidan, Holttinen, H., Tuohy, A., Gibescu, Madeleine, Holttinen, Hannele, O'Malley, M., Milligan, Michael R., Bernhard Lange, Kiviluoma, Juha, Aidan Tuohy, O'Malley, Mark, Mark O'Malley, Kiviluoma, J.   +26 more
core   +1 more source

Application of Energy Storage Systems to Enhance Power System Resilience: A Critical Review

Energies
The growing frequency and severity of extreme events, both natural and human-induced, have heightened concerns about the resilience of power systems.
Muhammad Usman Aslam, Md Sazal Miah, B. M. Ruhul Amin, Rakibuzzaman Shah, Nima Amjady   +4 more
doaj   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Boundary object or bridging concept? A citation network analysis of resilience [PDF]

, 2015
Many recent studies observe the increasing importance, influence, and analysis of resilience as a concept to understand the capacity of a system or individual to respond to change. The term has achieved prominence in diverse scientific fields, as well as
Brown, Katriana, Denis Hellebrandt, Katrina Brown, Jacopo A. Baggio, Baggio, Jacopo A., Hellebrandt, Denis   +5 more
core   +1 more source