Results 41 to 50 of about 471,361 (262)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Power System Controlled Islanding Using Directed Motif‐Based Spectral Clustering: A Novel Complex Network Perspective

IET Smart Grid
Intentional Controlled Islanding (ICI) is a wide‐area self‐healing strategy to prevent power system blackouts. Recent studies integrate ICI within a complex network framework using community detection techniques, thus addressing the complex nature of ...
Mohsen Safarzadeh, Gholam Reza Yousefi, Mohammad Amin Latify, Zeinab Maleki   +3 more
doaj   +1 more source

Determining the Load Inertia Contribution from Different Power Consumer Groups

Energies, 2020
Power system inertia is a vital part of power system stability. The inertia response within the first seconds after a power imbalance reduces the velocity of which the grid frequency changes.
Henning Thiesen, Clemens Jauch
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamic reactive power reserve assessment method for hybrid AC/DC networks based on a reduced equivalent model of an LCC‐HVDC converter process

IET Renewable Power Generation
LCC‐HVDC technology has been widely applied. Commutation failure is a common disturbance in converter stations. In the absence of an adequate and rapid dynamic reactive power supply, the system is prone to trigger DC blocking.
Sidun Fang, Yuli Lei, Tao Niu, Guanhong Chen, Lin Xue, Wenguo Wu, Nan Feng, Yuyao Feng   +7 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Small‐Signal Synchronization Stability Enhancement of GFL‐Based Renewable Energy Generation Using the Koopman Operator

IET Renewable Power Generation
Recent reports have highlighted small‐signal synchronous instability issues in grid‐following converter‐based renewable energy generation systems connected to weak power grids.
Le Zheng, Jiajie Zheng, Xin Liu, Gengyin Li, Yanhui Xu   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source