Results 41 to 50 of about 71,636 (296)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Tuning of Controllers in Power Systems Using a Heuristic-Stochastic Approach

Energies, 2019
A method is proposed to fit parameters of Power System Stabilizer controllers in electromechanical multimachine power systems. The use of the Non-dominated Sorting Genetic Algorithm II heuristic method and Tabu search is considered to be initial search ...
Humberto Verdejo, Rodrigo Torres, Victor Pino, Wolfgang Kliemann, Cristhian Becker, José Delpiano   +5 more
doaj   +1 more source

Simultaneous design of fuzzy PSS and fuzzy STATCOM controllers for power system stability enhancement

Alexandria Engineering Journal, 2022
The low frequency oscillations have always been the main problem of power system and can lead to power angle instability, limiting the maximum power to be transmitted on tie-lines and system separation.
Javad Ansari, Ali Reza Abbasi, Mohammd Hossein Heydari, Zakieh Avazzadeh   +3 more
doaj   +1 more source

Application of fuzzy logic to power system stabilizer [PDF]

, 2008
Power systems stability is a complex problem which was first recognised in 1920 and has been widely investigated by power system engineers ever since.
Abdullah, Shahrum Shah
core  

New heuristic-based design of robust power system stabilizers

, 2004
This paper proposes a new robust design of power system stabilizers (PSSs) in a multimachine power system using a heuristic optimization method. The structure of each PSS used is similar to that of a conventional lead/lag stabilizer.
Dechanupaprittha, Sanchai, Hongesombut, Komsan, Mitani, Yasunori, Ngamroo, Issarachai, Pasupa, Kitsuchart, Tippayachai, Jarurote   +5 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Penalaan Power System Stabilizer (PSS) untuk Perbaikan Stabilitas Dinamik pada Sistem Tenaga Listrik Menggunakan Bat Algorithm (BA) [PDF]

, 2015
Gangguan dinamik pada sistem tenaga listrik terjadi karena adanya Perubahan beban secara tiba-tiba dan periodik. Gangguan dinamik pada sistem tenaga listik tidak dapat direspon dengan baik oleh generator sehingga dapat mempengaruhi kestabilan dinamik ...
Priyadi, A. (Ardyono), Robandi, I. (Imam), Suharto, S. (Suharto)   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source