Results 71 to 80 of about 2,019,402 (349)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Power accretion in social systems [PDF]

Physical Review E, 2019
We consider a model of power distribution in a social system where a set of agents play a simple game on a graph: the probability of winning each round is proportional to the agent's current power, and the winner gets more power as a result. We show that, when the agents are distributed on simple 1D and 2D networks, inequality grows naturally up to a ...
Silvia N. Santalla, Kostadin Koroutchev, Elka Korutcheva, Javier Rodríguez-Laguna   +3 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Monitoring Pipeline Leaks Using Fractal Analysis of Acoustic Signals

Fractal and Fractional
This paper proposes a method for searching for pipeline leaks by analyzing the Hurst exponent of acoustic signals. The investigations conducted on the laboratory setup and the current pipelines of the water supply system.
Ayrat Zagretdinov, Shamil Ziganshin, Eugenia Izmailova, Yuri Vankov, Ilya Klyukin, Roman Alexandrov   +5 more
doaj   +1 more source

TSO-DSO coordination to acquire services from distribution grids : simulations, cost benefit analysis and regulatory conclusions from the SmartNet project [PDF]

, 2020
The continuously growing distributed generation and the business potential for demand response are gradually enabling significant provision of flexibility and reserve towards distribution networks.
Rossi, Marco, Siface, Dario, Migliavacca, Gianluigi, Morch, Andrei, Gómez, Inés, Madina, Carlos, Vigano, Giacomo, Kockar, Ivana   +7 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Detection of Pipeline Leaks Using Fractal Analysis of Acoustic Signals

Fractal and Fractional
In this paper, the possibility of using monofractal and multifractal analysis of acoustic signals of pipelines to detect leaks is considered. An experimental stand has been created to study the fractal characteristics of acoustic signals of pipelines ...
Ayrat Zagretdinov, Shamil Ziganshin, Eugenia Izmailova, Yuri Vankov, Ilya Klyukin, Roman Alexandrov   +5 more
doaj   +1 more source

CPES : Center Program Snapshot (April 2009)

, 2009
With the widespread use of power electronics technology, the United States would be able to cut electrical energy consumption by 33 percent. The energy savings, by today’s measure, is equivalent to the total output of 840 fossil fuel-based generating ...
Center for Power Electronics Systems
core