Results 81 to 90 of about 311,115 (293)

Evidence of the trade-off between starvation and predation risks in ducks

, 2011
The theory of trade-off between starvation and predation risks predicts a decrease in body mass in order to improve flight performance when facing high predation risk.
Zimmer, Cedric, Poulin Nicolas, Robin, JP, Zimmer Cédric, Mathieu Boos, Poulin, Nicolas, Zimmer, C, Boos Mathieu, Odile Petit, Cédric Zimmer, Andrew Gosler, Petit Odile, Petit, O, Gosler Andrew, Robin Jean-Patrice, Nicolas Poulin, Boos, Mathieu, Petit, Odile, Poulin, N, Jean-Patrice Robin, Gosler, Andrew, Robin, Jean-Patrice, Boos, M   +22 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Power Take-Off Safety

, 1995
The Power Take Off (PTO) Drive, found on most farm tractors, is a major power source for agricultural equipment. The PTO system efficiently transfers mechanical power from the tractor to the implement, but it may present serious hazards to persons who ...
Hallman, Eric, Demmin, Darcy M.
core  

Design, Construction and Testing of a Hydraulic Power Take-Off for Wave Energy Converters [PDF]

, 2012
This paper presents the construction, mathematical modeling and testing of a scaled universal hydraulic Power Take-Off (PTO) device for Wave Energy Converters (WECs). A specific prototype and test bench were designed and built to carry out the tests. The
Ricci, Pierpaolo, Estensoro, Patxi, Juan Carlos Antolin, Antolín-Urbaneja, Juan Carlos, Lasa, Joseba, Santos, Maider, Pierpaolo Ricci, Maider Santos, Angulo, Carlos, Carlos Angulo, Joseba Lasa, Antolín Urbaneja, Juan Carlos, Angulo Duque, Carlos, Patxi Estensoro   +13 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Optimum wave energy conversion of a point absorber with direct electrical power take-off

, 2020
This paper refers to the passive and reactive control of power-take-off (PTO) systems involved in wave energy conversion. A point-absorber device (buoy) is considered.
Di Leonardo L., Parasiliti Collazzo F., Tursini M., Villani M., Credo A.   +4 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Off Peak Power - An Alternative to Interruptible Service

, 1984
Georgia Power's Off-Peak Rider encourages load reductions up to 40% during on-peak periods over four summer months each year. Since summer on-peak time represents about 50% of available time, the customer's productive summer capacity may be reduced 20 ...
Nordyke, H. G., Jr.
core  

Implementation of a Hydraulic Power Take-Off for wave energy applications [PDF]

, 2013
The main purpose of the following work is to implement a hydraulic power take-off system coupled with the dynamic model of a wave energy converter. In this work the Wavestar concept will be used without any losses of the general principle since the power
Kracht, Peter, Ferri, Francesco
core   +1 more source