Results 61 to 70 of about 17,489 (250)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Technical specifications for the procurement of power transformers [PDF]

Zbornik Radova: Elektrotehnički Institut "Nikola Tesla"
This paper analyzes the provisions and significance of Internal Standard IS 2, which defines the electrotechnical requirements and methodology for developing technical specifications for the procurement of new and the revitalization of existing power ...
Ristić Mihajlo, Maksimović Slobodan, Pejović Branko, Jovanović Đorđe, Teslić Dragan, Radojčić Miroslav, Radin Vesna   +6 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Optimal Current Distribution in Multi-Winding Transformers for Isolated and Wireless Power Transfer

IEEE Open Journal of Power Electronics
This work explores the modeling and optimization of multi-winding transformers which may be used for high-frequency isolated power conversion and wireless power transfer.
Kishalay Datta, Yue Wu, Charles R. Sullivan, Jason T. Stauth   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of drying methods of oil-oiled power transformers [PDF]

E3S Web of Conferences
The article describes the influence of power transformers on the energy system, the condition of the insulation system to ensure their reliable operation.
Yusupov D.T., Muminov A.B., Sa’dullayev A.B., Norboev A.E., Babaev O.E.   +4 more
doaj   +1 more source

Determination of Transformer Oil Contamination from the OLTC Gases in the Power Transformers of a Distribution System Operator

Applied Sciences, 2020
Power transformers are considered to be the most important assets in power substations. Thus, their maintenance is important to ensure the reliability of the power transmission and distribution system.
Sergio Bustamante, Mario Manana, Alberto Arroyo, Alberto Laso, Raquel Martinez   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source