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Mpox: disease manifestations and therapeutic development. [PDF]
J VirolWang Y +5 more
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Nature Reviews Microbiology, 2005 Despite the success of the WHO-led smallpox eradication programme a quarter of a century ago, there remains considerable fear that variola virus, or other related pathogenic poxviruses such as monkeypox, could re-emerge and spread disease in the human population.
Grant Mcfadden, Mcfadden Grant
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The Evolution of Poxvirus Vaccines [PDF]
Viruses, 2015 After Edward Jenner established human vaccination over 200 years ago, attenuated poxviruses became key players to contain the deadliest virus of its own family: Variola virus (VARV), the causative agent of smallpox. Cowpox virus (CPXV) and horsepox virus (HSPV) were extensively used to this end, passaged in cattle and humans until the appearance of ...
BEATRIZ Perdiguero +2 more
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Ribosomes in poxvirus infection
Current Opinion in Virology, 2022Poxviruses are large double-stranded DNA viruses that encode their own DNA replication, transcription, and mRNA biogenesis machinery, which underlies their ability to replicate entirely in the cytoplasm. However, like all other viruses, poxviruses remain dependent on host ribosomes to translate their mRNAs into the viral proteins needed to complete ...
Chorong, Park, Derek, Walsh
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1969
Only a short time has elapsed since the poxvirus literature was reviewed in a most thorough and comprehensive fashion (Joklik, 1966). It is the purpose of this communication to focus in somewhat more detail on a single facet of the overall picture, the poxvirus-coded proteins or antigens.
W C, Wilcox, G H, Cohen
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Only a short time has elapsed since the poxvirus literature was reviewed in a most thorough and comprehensive fashion (Joklik, 1966). It is the purpose of this communication to focus in somewhat more detail on a single facet of the overall picture, the poxvirus-coded proteins or antigens.
W C, Wilcox, G H, Cohen
openaire +2 more sources
Recent Patents on Anti-Infective Drug Discovery, 2006
Despite many advances in chemotherapy and other medical techniques, patients with cancer often develop local recurrence or metastatic spread. Recent advances in molecular biology and tumor immunology have led to the design of many new anti-tumor vaccines. Such approaches are now using recombinant viruses to treat different types of cancer.
Philippe-Alexandre, Gilbert +1 more
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Despite many advances in chemotherapy and other medical techniques, patients with cancer often develop local recurrence or metastatic spread. Recent advances in molecular biology and tumor immunology have led to the design of many new anti-tumor vaccines. Such approaches are now using recombinant viruses to treat different types of cancer.
Philippe-Alexandre, Gilbert +1 more
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POXVIRUS INFECTION AND APOPTOSIS
International Reviews of Immunology, 2004The following excellent reviews have been published on poxviruses and apoptosis during the last few years: P.C. Turner and R.W. Moyer, Semin. Virology, 8: 453-469, 1998; J.L. Shisler and B. Moss, Semin. Immunol., 13: 67-72, 2001; and H. Everett and G. McFadden, Curr. Opin. Microbiol., 5: 395-402, 2002.
Beatriz G-T, Pogo +2 more
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Poxvirus oncolytic virotherapy
Expert Opinion on Biological Therapy, 2019Over the last decade, advances in biological therapies have resulted in remarkable clinical responses for the treatment of some previously incurable cancers. Oncolytic virotherapy is one of these promising novel strategies for cancer therapy. A successful oncolytic virus promotes tumor cell oncolysis and elicits a robust long-term anti-tumor immunity ...
Lino E, Torres-Domínguez +1 more
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2004
Biochemical and functional analysis of poxvirus genomes, genes, and proteins has entered a new era with the recent sequencing of more than 30 poxvirus genomes. The management and analysis of this volume of sequence data in an efficient and effective manner requires specialized computer software.
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Biochemical and functional analysis of poxvirus genomes, genes, and proteins has entered a new era with the recent sequencing of more than 30 poxvirus genomes. The management and analysis of this volume of sequence data in an efficient and effective manner requires specialized computer software.
openaire +2 more sources