Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150 [PDF]
Strong under pressure Human cytomegalovirus (HCMV) is a member of the herpesvirus family that can cause life-threatening infections in those who are immunocompromised. HCMV encodes a genome that is about 50% larger than that of herpes simplex virus 1 (the virus that causes cold sores), but these two viruses have ...
Xuekui Yu +2 more
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Control of Cytoplasmic Maturation Events by Cytomegalovirus Tegument Protein pp150 [PDF]
ABSTRACT Cytomegalovirus replication depends upon a betaherpesvirus-conserved 150-kDa tegument phosphoprotein (pp150; encoded by UL32) that supports the final steps in virion maturation at cytoplasmic assembly compartments. Amino acid substitutions were introduced into conserved region 1 (CR1) and CR2 of pp150, affecting a region
Ritesh Tandon
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Human cytomegalovirus structural proteins: immune reaction against pp150 synthetic peptides [PDF]
In the present study, several peptides of the major structural antigen (pp150) of human cytomegalovirus (CMV) have been chemically synthesized and tested by a modified slot blotting procedure for their ability to bind CMV-specific immunoglobulin G (IgG) and IgM present in human sera. The sequences of the peptides were deduced on the basis of either (i)
M P Landini
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Bicaudal D1-Dependent Trafficking of Human Cytomegalovirus Tegument Protein pp150 in Virus-Infected Cells [PDF]
ABSTRACT Human cytomegalovirus (HCMV) virion assembly takes place in the nucleus and cytoplasm of infected cells. The HCMV virion tegument protein pp150 (ppUL32) is an essential protein of HCMV and has been suggested to play a role in the cytoplasmic phase of HCMV assembly.
Mary E Ballestas, William J Britt
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Objective To evaluate the effectiveness of prokaryotic expression of fusion proteins pp150-pp65 of human cytomegalovirus (hCMV) for its application as antigen, the fusion protein of pp150-pp65 were expressed in prokaryotic expression system and purified by Ni-NTA affinity chromatography column for preparing the colloidal gold kit.
Yan Hua, Ting Yu, Hua Yan
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PP150 Rapid Analgesia For Prehospital Hip Disruption: A Feasibility Study
International Journal of Technology Assessment in Health Care, 2017INTRODUCTION:Adequate pain relief at the scene of injury and during transport to hospital is a major challenge in all acute traumas, especially for those with hip fractures, whose injuries are difficult to immobilize and long-term outcomes may be adversely affected by administration of opiate analgesics.
Jenna Bulger +13 more
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Betaherpesvirus-Conserved Cytomegalovirus Tegument Protein ppUL32 (pp150) Controls Cytoplasmic Events during Virion Maturation [PDF]
ABSTRACT The UL32 gene of human cytomegalovirus (CMV) encodes a prominent betaherpesvirus-conserved virion tegument protein, called pp150 (basic phosphoprotein/ppUL32), that accumulates within a cytoplasmic inclusion adjacent to the nucleus at late times during infection.
David P Aucoin
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The development of HCMV vaccines for the prevention of congenital HCMV has been identified as a top priority by the Institute of Medicine (USA), and virus infection is an important endpoint for the efficacy evaluation of the candidate vaccines. However, it is technically difficult to capture the HCMV viremia or uremia in infected individuals because ...
Ge Shengxiang +2 more
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PP150 Bevan Health Technology Exemplars: Early Dialogue To Systematize HTA
International Journal of Technology Assessment in Health Care, 2019IntroductionWales has ambitious health, wealth, and innovation policies and a clear goal to use the economic muscle of the Welsh National Health Service (NHS) to support its strong life sciences sector. Health Technology Wales (HTW) has a clear remit to appraise technologies over the span of their lifecycle from innovation to obsolescence.
Susan Myles +5 more
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PP150. Pregnancy outcome in women with heart disease in a single tertiary care center
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2012The number of women presenting with cardiac disease during pregnancy is increasing because more women with repaired congenital heart disease are reaching childbearing age and because of more pregnancies occurring in women with ischemic heart disease. Cardiac disease is the leading cause of indirect maternal mortality in the Netherlands.Clinical data of
E, Hink, S H, Luitjes, A C, Bolte
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