Results 141 to 150 of about 33,868 (177)

Effects of PPARα, PPARγ, and dual PPARα/γ agonists on liver tissue and biochemical markers in NAFLD-induced Wistar rats. [PDF]

Res Pharm Sci
Khoshbakht E, Dinarvand N, Yaghooti H, Taheri B, Mohammadtaghvaei N.   +4 more
europepmc   +1 more source

“Humanizar”: aprendizajes sobre alteridad, salud y futuro en una experiencia de investigación compartida

The Journal of Latin American and Caribbean Anthropology, Volume 31, Issue 2, June 2026.
ABSTRACT The visit to Bogotá of a fééeneminaa (Muinane) friend, Célimo Nejedeka Jifichíu, and in particular, his work in researching and transmitting traditional health knowledge, offer the pretext to navigate the relationship between elements that at first glance seem distant from each other: indigenous imaginaries about otherness, their visions of ...
Giovanna Micarelli
wiley   +1 more source

L-Leucine Upregulates Lysosomal Biogenesis and Autophagy to Lower Plaques in 5XFAD Mouse Model of Alzheimer's Disease. [PDF]

J Neurochem
Paidi RK, Gorai S, Mondal S, Pahan K.
europepmc   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

Hepatocyte PPARα Is Essential for Triglyceride-Lowering Effect of Pemafibrate. [PDF]

Int J Mol Sci
Zhang Z, Zhang X, Qian C, Diao P, Nakajima T, Kimura T, Gonzalez FJ, Tanaka N.   +7 more
europepmc   +1 more source

Chronic attenuation of brain leptin signalling is associated with early metabolic dysfunction in lean rats

The Journal of Physiology, Volume 604, Issue 12, Page 4717-4744, 15 June 2026.
Abstract figure legend Central leptin signalling blockade induces early metabolic dysfunction. Intracerebroventricular infusion of a leptin receptor antagonist (SLA) in rats disrupts hypothalamic leptin signalling, leading to reduced signal transducer and activator of transcription 3 (STAT3) activation, decreased Socs3 and Pomc expression, and ...
Cristina Pintado, Lorena Mazuecos, Óscar Gómez‐Torres, Beatriz Merino, Elena Casanueva‐Álvarez, Blanca Rubio, Emma Burgos‐Ramos, Sara Artigas‐Jerónimo, Eduardo Moltó, Inés María Ramos, Justa María Poveda, Germán Perdomo, Irene Cózar‐Castellano, Carmen Arribas, Ernesto Bernal‐Mizrachi, Antonio Andrés, Nilda Gallardo   +16 more
wiley   +1 more source

Development of a QSAR model for predicting PPARα activation by PFAS based on human in vitro data of a comprehensive panel of legacy and novel PFAS. [PDF]

Arch Toxicol
Alker W, Tsiros P, Sarimveis H, Braeuning A, Buhrke T.   +4 more
europepmc   +1 more source

CXCL6 exacerbates metabolic dysfunction-associated steatohepatitis by suppressing LPIN1-mediated fatty acid oxidation in hepatocytes. [PDF]

Int J Biol Sci
Cho YE, Kim MJ, Kim Y, Lim H, Park Y, Kim S, Kim SJ, Yoo JW, Ryu S, Song P, Hong C, He Y, Lee H, Cho JY, Hwang S.   +14 more
europepmc   +1 more source

PFAS Toxicity: What's True, What's Not, and What Really Matters. [PDF]

Environ Sci Technol
DeWitt JC, Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Scheringer M, Trier X, Wang Z.   +9 more
europepmc   +1 more source

Electroacupuncture activates the TET1/PPARα pathway to protect mitochondrial function in MASLD. [PDF]

J Inflamm (Lond)
Yang S, Li Y, Lu B, Cheng C, Wang Y, Chen L.   +5 more
europepmc   +1 more source