Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia [PDF]
EBioMedicine, 2020 Background: The pathophysiology of schizophrenia, a major psychiatric disorder, remains elusive. In this study, the role of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor (RXR) families, belonging to the ligand-activated nuclear ...
Yuina Wada +15 more
doaj +4 more sources
Peroxisome Proliferator-Activated Receptor α in Lipoprotein Metabolism and Atherosclerotic Cardiovascular Disease [PDF]
Biomedicines, 2023 Peroxisome proliferator-activated receptors (PPARs) are a group of ligand-binding transcription factors with pivotal action in regulating pleiotropic signaling pathways of energetic metabolism, immune responses and cell proliferation and differentiation.
Elena Valeria Fuior +7 more
doaj +2 more sources
Peroxisome Proliferator–Activated Receptor-α: A Pivotal Regulator of the Gastrointestinal Tract [PDF]
Frontiers in Molecular Biosciences, 2022 Peroxisome proliferator–activated receptor (PPAR)-α is a ligand-activated transcription factor distributed in various tissues and cells. It regulates lipid metabolism and plays vital roles in the pathology of the cardiovascular system. However, its roles
Yue-Xin Guo +7 more
doaj +2 more sources
Salidroside Ameliorates Cardiomyocyte Hypertrophy by Upregulating Peroxisome Proliferator-Activated Receptor-α [PDF]
Frontiers in Pharmacology, 2022 Cardiac hypertrophy is an adaptive change in response to pressure overload, however the hypertrophy may evolve toward heart failure if cannot be corrected as soon as possible.
Hui Gao +5 more
doaj +2 more sources
Impact of peroxisome proliferator-activated receptor-α on diabetic cardiomyopathy [PDF]
Cardiovascular Diabetology, 2021 The prevalence of cardiomyopathy is higher in diabetic patients than those without diabetes. Diabetic cardiomyopathy (DCM) is defined as a clinical condition of abnormal myocardial structure and performance in diabetic patients without other cardiac risk
Lin Wang +5 more
doaj +2 more sources
Peroxisome Proliferator-Activated Receptor α Activation Protects Retinal Ganglion Cells in Ischemia-Reperfusion Retinas [PDF]
Frontiers in Medicine, 2021 Background and Objective: Retinal ischemia-reperfusion (IR) leads to massive loss of retinal ganglion cells (RGC) and characterizes several blind-causing ophthalmic diseases.
Fei Yao +18 more
doaj +2 more sources
Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α [PDF]
Cells, 2020 Alzheimer’s disease (AD) is the leading cause of dementia in the elderly. Mutations in genes encoding proteins involved in amyloid-β peptide (Aβ) production are responsible for inherited AD cases.
Francisco Sáez-Orellana +2 more
doaj +2 more sources
Corrigendum: Peroxisome proliferator–activated receptor-α: A pivotal regulator of the gastrointestinal tract [PDF]
Frontiers in Molecular Biosciences, 2022 Yue-Xin Guo +7 more
doaj +2 more sources
Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy [PDF]
Diabetes & Metabolism Journal, 2011 With a developing worldwide epidemic of diabetes mellitus, the renal complications associated with diabetes have become a serious health concern. Primary therapy for treating diabetic nephropathy is a multifactorial process.
Sungjin Chung, Cheol Whee Park
doaj +1 more source
Stimulation of Alpha-1-Adrenergic Receptor Ameliorates Obesity-Induced Cataracts by Activating Glycolysis and Inhibiting Cataract-Inducing Factors [PDF]
Endocrinology and Metabolism, 2022 Background Obesity, the prevalence of which is increasing due to the lack of exercise and increased consumption of Westernized diets, induces various complications, including ophthalmic diseases. For example, obesity is involved in the onset of cataracts.
Yong-Jik Lee +8 more
doaj +1 more source