Results 21 to 30 of about 72,675 (217)

Peroxisome proliferator-activated receptor α controls cellular cholesterol trafficking in macrophages

Journal of Lipid Research, 2005
The mobilization of cholesterol from intracellular pools to the plasma membrane is a determinant that governs its availability for efflux to extracellular acceptors.
G. Chinetti-Gbaguidi, E. Rigamonti, L. Helin, A.L. Mutka, M. Lepore, J.C. Fruchart, V. Clavey, E. Ikonen, S. Lestavel, B. Staels   +9 more
doaj   +1 more source

Effect of berberine on PPARα-NO signalling pathway in vascular smooth muscle cell proliferation induced by angiotensin IV

Pharmaceutical Biology, 2017
Context: The available treatments for the abnormal proliferation of vascular smooth muscle cells (VSMCs) are still dismal. Berberine has been demonstrated to possess extensive medicine activity, yet relatively little is known about its effect on VSMCs ...
Hongmei Qiu, Yang Wu, Quanhua Wang, Changqing Liu, Lai Xue, Hong Wang, Qin Wu, Qingsong Jiang   +7 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor α (PPARα) down-regulation in cystic fibrosis lymphocytes

Respiratory Research, 2006
Background PPARs exhibit anti-inflammatory capacities and are potential modulators of the inflammatory response. We hypothesized that their expression and/or function may be altered in cystic fibrosis (CF), a disorder characterized by an excessive host ...
Wagner Thomas, Steinhauer Constanze, Loitsch Stefan, Reynders Veerle, Steinhilber Dieter, Bargon Joachim   +5 more
doaj   +1 more source

Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity

Pharmacological Research
Metabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie, Nana Yan, Frank J. Gonzalez, Haiping Hao, Tingting Yan   +4 more
doaj   +1 more source

Peroxisome proliferator-activated receptor α polymorphisms and postprandial lipemia in healthy men

Journal of Lipid Research, 2007
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-dependent transcription factor that plays a key role in lipid and glucose homeostasis. This study evaluated whether variants of PPARα are associated with postprandial lipemia. Subjects were
Toshiko Tanaka, Jose M. Ordovas, Javier Delgado-Lista, Francisco Perez-Jimenez, Carmen Marin, Pablo Perez-Martinez, Purificacion Gomez, Jose Lopez-Miranda   +7 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Targeting Peroxisome Proliferator Activated Receptor α (PPAR α) for the Prevention of Mitochondrial Impairment and Hypertrophy in Cardiomyocytes

Cellular Physiology and Biochemistry, 2018
Background/Aims: Morphological and biochemical maladaptation of cardiomyocytes are associated with mitochondrial dysfunction and dysregulation in hypertrophic conditions.
Dipak Kar, Arun  Bandyopadhyay
doaj   +1 more source

Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect. [PDF]

PLoS ONE, 2014
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, ranging from steatosis to steatohepatitis and cirrhosis.
Fang Yan, Qi Wang, Chao Xu, Mingfeng Cao, Xiaoming Zhou, Tingting Wang, Chunxiao Yu, Fei Jing, Wenbin Chen, Ling Gao, Jiajun Zhao   +10 more
doaj   +1 more source

Additional file 1: of Associations between hypertension and the peroxisome proliferator-activated receptor-δ (PPARD) gene rs7770619 C>T polymorphism in a Korean population

, 2018
Table S1. Top 10 SNPs associated with plasma MDA. Figure S1. Flow of the study participants. (DOCX 112 kb)
Kim, Minjoo, Kim, Minkyung, Yoo, Hye, Shon, Jayoung, Lee, Jong   +4 more
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source