Results 1 to 10 of about 33,868 (177)

Pleiotropic effects of PPAR-α – from benchside to bedside

Медицинская иммунология, 2021
Here we review literature data on properties of a member of nuclear hormone receptors - peroxisome proliferator-activated receptor-α. It was shown that PPARα was expressed on different cells including dendritic cells, macrophages, B- and T-cells.
I. V. Shirinsky, V. S. Shirinsky
doaj   +1 more source

L-Carnitine Is Involved in Hyperbaric Oxygen-Mediated Therapeutic Effects in High Fat Diet-Induced Lipid Metabolism Dysfunction

Molecules, 2020
Lipid metabolism dysfunction and obesity are serious health issues to human beings. The current study investigated the effects of hyperbaric oxygen (HBO) against high fat diet (HFD)-induced lipid metabolism dysfunction and the roles of L-carnitine.
Junhua Yuan, Qixiao Jiang, Limin Song, Yuan Liu, Manwen Li, Qian Lin, Yanrun Li, Kaizhen Su, Zhengye Ma, Yifei Wang, Defeng Liu, Jing Dong   +11 more
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Synthesis of DHA (omega-3 fatty acid): FADS2 gene polymorphisms and regulation by PPARα

Oilseeds and fats, crops and lipids, 2021
In humans, in several biological systems, in particular the nervous system, the FADS2 gene transcribes Δ6-desaturase, which is the rate-limiting enzyme for converting α-linolenic acid into docosahexaenoic acid (an n-3 fatty acid).
Majou Didier
doaj   +1 more source

Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. [PDF]

PLoS ONE, 2015
The nuclear receptor family member peroxisome proliferator-activated receptor α (PPARα) is activated by therapeutic hypolipidemic drugs and environmentally-relevant chemicals to regulate genes involved in lipid transport and catabolism.
Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton   +10 more
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PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice

Molecules, 2020
Metformin is the first-line drug for type 2 diabetes mellitus control. It is established that this drug traffics through OCT-2 and MATE-1 transporters in kidney tubular cells and is excreted in its unaltered form in the urine. Hereby, we provide evidence
Adriano Cleis Arruda, Mauro Sérgio Perilhão, Warley Almeida Santos, Marcos Fernandes Gregnani, Alexandre Budu, José Cesar Rosa Neto, Gabriel Rufino Estrela, Ronaldo Carvalho Araujo   +7 more
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The Effect of Curcuma and Garcinia Peel on Rat PPARα Gene Expression Induced by High-Fat Diet

Global Medical & Health Communication, 2023
High levels of fat in the blood are a risk factor for nonalcoholic steatohepatitis liver disease. Indonesian medicinal plants that can decrease blood fat levels are turmeric and mangosteen peel.
Diana Krisanti Jasaputra, Hoo Yumilia, Julia Windi Gunadi, Ronny Lesmana, Andieni Faqhira Permadi   +4 more
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Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level

Czech Journal of Animal Science, 2014
A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3-hydroxy-3-methyl-glutaryl-CoA reductase (Hmgcr) and ...
T. Komprda, G. Zorníková, A. Knoll, Z. Vykoukalová, V. Rozíková, O. Škultéty, R. Krobot   +6 more
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Identification of a novel regulatory pathway for PPARα by RNA-seq characterization of the endothelial cell lipid peroxidative injury transcriptome [PDF]

Open Biology, 2019
Endothelial dysfunction caused by endothelial cell injuries is the initiating factor for atherosclerosis (AS), and lipid peroxidative injury is one of a dominant factor for AS pathogenesis.
Fangfang Dou, Beiling Wu, Lin Sun, Jiulin Chen, Te Liu, Zhihua Yu, Chuan Chen   +6 more
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The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis

BioMedicine, 2019
Background: The activation of peroxisome proliferator-activated receptor alpha (PPARα) has been shown to reprogram tumor metabolism and exhibits great potential for treating anti-oral tumorigenesis.
Chang Nai-Wen, Huang Yi-Ping
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Critical role of peroxisome proliferator-activated receptor α in promoting platelet hyperreactivity and thrombosis under hyperlipidemia

Haematologica, 2021
Platelet hyperreactivity and increased atherothrombotic risk are specifically associated with dyslipidemia. Peroxisome proliferator-activated receptor alpha (PPARα) is an important regulator of lipid metabolism.
Li Li, Jiawei Zhou, Shuai Wang, Lei Jiang, Xiaoyan Chen, Yangfan Zhou, Jingke Li, Jingqi Shi, Pu Liu, Zheyue Shu, Frank J. Gonzalez, Aiming Liu, Hu Hu   +12 more
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