Results 181 to 190 of about 114,575 (218)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

RT206 Couples Partial PPARα/γ Agonism with Ligand-Dependent Allosteric Potentiation of FXR Signaling in Liver Cells. [PDF]

Biomolecules
Leo M, Cerchia C, Laghezza A, Rinaldi F, Calleri E, Colantuoni V, Loiodice F, Sabatino L, Lavecchia A.   +8 more
europepmc   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

From Molecular Mechanisms to Clinical Strategies: A Comprehensive Overview of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

Int J Mol Sci
Świerczek D, Dreger M, Jatkowski J, Kancerek J, Drozdzowska B, Wojnicz R.   +5 more
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Design, Synthesis and Antihyperglycemic/Antilipidemic Activities of Quinoline-thiazolidine-2,4-dione Hybrid. [PDF]

Pharmaceuticals (Basel)
Abousaada EAM, Galal-Khallaf A, Mohammed-Geba K, El-Bahnsawye M, Hussein MKA, Elmongy EI, Shaltout RAA, Binsuwaidan R, Ali H, El-Tantawy AI, Abdel-Bary H, Tantawy El Sayed IE.   +11 more
europepmc   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Pterostilbene Combating Cyclophosphamide-Induced Central Neuro-Inflammation in Rats: Effect on GFAP, PPAR- γ, NLRP3, COX-2 and Nrf2/HO-1 Pathway. [PDF]

Biomedicines
Ahmed RF, Farouk H, Hussien YA, Shabana ME, Nasr M.   +4 more
europepmc   +1 more source

Trends and Approaches in Obesity and Overweight Research Focused on White Adipose Tissue and Browning: A Bibliometric Study

Obesity Reviews, EarlyView.
ABSTRACT The global rise in obesity has intensified scientific interest in adipose tissue biology, particularly the mechanisms underlying white adipose tissue (WAT) browning. This bibliometric study mapped the evolution, structure, and emerging directions of research on obesity, overweight, and WAT browning from 2011 to May 2025. Records were retrieved
Violeta Heras, Daniel Hinojosa‐Nogueira, Francisco J. Tinahones, Isabel Moreno‐Indias   +3 more
wiley   +1 more source