Results 51 to 60 of about 114,575 (218)

Systematic Literature Riview: Peranan metode BIM dalam Integrated Project Delivery (IPD) untuk Mengoptimalkan Konstruktabilitas Proyek

Jurnal Teknik Sipil
Kemajuan teknologi informasi dalam industri konstruksi mendorong penggunaan Building Information Modeling (BIM) dalam proyek dengan metode Integrated Project Delivery (IPD) untuk meningkatkan efektivitas dan efisiensi pelaksanaan proyek.
GUSLIAINI ALIFIA PAMBUDI, Faiz Hamdi Suprahman   +1 more
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Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism

PPAR Research, 2010
PPAR-α, PPAR-β, and PPAR-γ, and RXR in conjunction with PGC-1α and SIRT1, activate oxidative metabolism genes determining insulin sensitivity. In utero, hypoxia is commonly observed in Intrauterine Growth Restriction (IUGR), and reduced insulin ...
Timothy R. H. Regnault, Lin Zhao, Jacky S. S. Chiu, Stephanie K. Gottheil, Allison Foran, Siu-Pok Yee   +5 more
doaj   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression

Journal of Dairy Science
: The objective of this study was to evaluate the possible role of the peroxisome proliferator-activated receptors (PPAR: PPAR-α, PPAR-β/δ, and PPAR-γ) in diet and CLA-induced milk fat depression (MFD) in dairy cows.
A. Haile, D.E. Oliveira, Y.R. Boisclair, D.E. Bauman, K.J. Harvatine   +4 more
doaj   +1 more source

Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids

Frontiers in Immunology, 2018
Although glucocorticoids (GC) represent the most frequently used immunosuppressive drugs, their effects are still not well understood. In our previous studies, we have shown that treatment of monocytes with GC does not cause a global suppression of ...
Michael Heming, Michael Heming, Sandra Gran, Saskia-L. Jauch, Lena Fischer-Riepe, Antonella Russo, Luisa Klotz, Sven Hermann, Michael Schäfers, Johannes Roth, Katarzyna Barczyk-Kahlert   +10 more
doaj   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders

PPAR Research, 2008
Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension.
Min-Chul Cho, Kyoung Lee, Sang-Gi Paik, Do-Young Yoon   +3 more
doaj   +1 more source

Cellular, Molecular Consequences of Peroxisome Proliferator- Activated Receptor-δ Activation in Ovarian Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2006
Peroxisome proliferator-activated receptor-δ (PPAR-δ) is a ligand-activated transcription factor. In addition to its canonical role in lipid, glucose metabolism, PPAR-δ controls cell proliferation, death, differentiation in several tissues.
Sara Vignati, Veronica Albertini, Andrea Rinaldi, Ivo Kwee, Cristina Riva, Rita Oldrini, Carlo Capella, Francesco Bertoni, Giuseppina M. Carbone, Carlo V. Catapano   +9 more
doaj   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors [PDF]

Eurasian Journal of Veterinary Sciences
Aim: The study objectives were to determine whether dietary supplementation with long chain omega-3 polyunsaturated fatty acids in the form of enriched fish oil (FO) for 90 days or treatment with bovine somatotropin (bST) at the time of ovulation and 11 ...
Leslie A. MacLaren, Todd R. Bilby, Frank Michel, Aydin Guzeloglu, Charles R. Staples, William W. Thatcher   +5 more
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