Results 81 to 90 of about 23,167 (255)

Mutation in the PPARG ligand binding domain impairs PPARG‐mediated turnover of the p65 subunit of NF‐κB (930.2)

The FASEB Journal, 2014
PPARG is a ligand activated transcriptional factor known to regulate metabolism. A recent study suggests that PPARG may elicit its anti‐inflammatory activity by promoting the degradation of the p65 subunit of nuclear factor kappa B (NF‐kB). We previously demonstrated that transgenic mice expressing dominant negative PPARG in vascular muscle (S‐P467L ...
Masashi Mukoda, Madeliene Stump, Pimonrat Ketsawatsomkron, Federick Quelle, Curt Sigmund   +4 more
openaire   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Effect of IL-17A and PPARG gene polymorphism on the course of purulent complications after treatment of patients with lower limb bone injuries

Гений oртопедии
Introduction Epidemiological studies have shown a link between genetic factors and the development of purulent complications after treatment in traumatology and orthopedics.
Vitaly V. Savgachev, Leonid B. Shubin
doaj   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Aaptamine Inhibits Lipid Accumulation and Pparg and Slc2a4 Expression While Maintaining the Methylation of the Pparg Promoter During 3T3-L1 Adipocyte Differentiation

Journal of Experimental Pharmacology
Eko Fuji Ariyanto,1 Ibnu Wijaya,2 Zaky Alif Pradian,2 Agung Putri Mayasari Bhaskara,2 Mohammad Parezal Lastialno,3 Putri Halleyana Adrikni Rahman,1 Muhammad Hasan Bashari,1 Nandina Oktavia,1 Muhammad Iman Pratama Putra,4 Yuni Susanti Pratiwi,1 Henhen ...
Ariyanto EF, Wijaya I, Pradian ZA, Bhaskara APM, Lastialno MP, Rahman PHA, Bashari MH, Oktavia N, Putra MIP, Pratiwi YS, Heryaman H, Dhianawaty D   +11 more
doaj  

Guidelines for High‐Throughput Screening for Natural Products With Anti‐Aging Activity Based on Drosophila Intestinal Homeostasis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Aging represents a critical risk factor for chronic diseases, driving an urgent demand for interventions promoting healthy longevity. This study establishes standardized guidelines for high‐throughput screening (HTS) of anti‐aging natural products using Drosophila melanogaster, leveraging its intestinal homeostasis as a biomarker.
Xiao Sheng, Lei Zhang
wiley   +1 more source

Pancreatic Atrophy: A Narrative Review and Surgical Interpretation

Annals of Gastroenterological Surgery, EarlyView.
Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino, Ken‐ichi Okada, Yohei Masugi, Eisuke Iwasaki, Masaki Mori   +4 more
wiley   +1 more source

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source

The Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor Gamma Gene Modifies the Association of Physical Activity and Body Mass Changes in Polish Women

PPAR Research, 2014
Peroxisome proliferator-activated receptor γ is a key regulator of adipogenesis, responsible for fatty acid storage and maintaining energy balance in the human body.
Aleksandra Zarebska, Zbigniew Jastrzebski, Pawel Cieszczyk, Agata Leonska-Duniec, Katarzyna Kotarska, Mariusz Kaczmarczyk, Marek Sawczuk, Agnieszka Maciejewska-Karlowska   +7 more
doaj   +1 more source

Effects of PPARg agonist pioglitazone on rat hepatic fibrosis

World Journal of Gastroenterology, 2004
To investigate effects of pioglitazone on rat hepatic fibrosis and to explore its mechanism.Rat hepatic fibrosis was induced by carbon tetrachloride (CCl(4)). Forty Sprague-Dawley rats were divided randomly into 4 groups: control, model, and two treatment (PI, PII) groups.
Guang-Jin, Yuan, Ming-Liang, Zhang, Zuo-Jiong, Gong   +2 more
openaire   +2 more sources