Results 131 to 140 of about 1,756 (151)

LncRNA SNHG7 alleviates IL-1β-induced osteoarthritis by inhibiting miR-214-5p-mediated PPARGC1B signaling pathways

International Immunopharmacology, 2021
As a common joint disease, osteoarthritis (OA) is the main cause of limited joint mobility and disability. The role of lncRNAs in the regulation of OA is increasingly discovered. Therefore, further exploring the function of SNHG7 in OA is of great significance for understanding its occurrence and development.We used interleukin-1β (IL-1β) to treat to ...
Xiaojun Liang
exaly   +3 more sources

Analysis of Clinical Indexes and RUNX3 , TBKBP1 , PPARGC1B Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis

Genetic Testing and Molecular Biomarkers, 2015
Ankylosing spondylitis (AS) is a genetically determined disease. Runt-related transcription factor 3 (RUNX3), tumor necrosis factor family member-associated NF-κB activator binding kinase 1 binding protein (TBKBP1), and peroxisome proliferator-activated receptor-gamma coactivator 1 beta (PPARGC1B) have recently been found to be associated with ...
Wei Chai
exaly   +2 more sources

Assessment of PPARGC1A , PPARGC1B , and PON1 Genetic Polymorphisms in Esophageal Squamous Cell Carcinoma Susceptibility in the Eastern Chinese Han Population: A Case–Control Study Involving 2351 Subjects

DNA and Cell Biology, 2020
Previous studies suggested that alterations in the energy metabolism might be underlying cancer initiation and progression. Polymorphisms of genes involved in energy metabolism regulation, such as peroxisome proliferator-activated receptor gamma coactivator 1α (PPARGC1A), -β (PPARGC1B), and paraoxonase 1 (PON1), might confer susceptibility to ...
Weifeng Tang
exaly   +2 more sources

Functional Characterization of Exonic Variants of the PPARGC1B Gene in Coregulation of Estrogen Receptor Alpha

DNA and Cell Biology, 2016
Peroxisome proliferator-activated receptor gamma coactivator 1 beta (PPARGC1B) is a coactivator of estrogen receptor (ER)α and ERβ. We previously demonstrated a significant association between a variant of exon 5 of the PPARGC1B gene (+102525 G>A, R265Q) and airway hyperreactivity (AHR).
Hun Soo, Chang, Shin-Hwa, Lee, Jong-Uk, Lee, Jong Sook, Park, Il Yup, Chung, Choon-Sik, Park   +5 more
openaire   +2 more sources

Genetic effect of single‐nucleotide polymorphisms in the PPARGC1B gene on airway hyperreactivity in asthmatic patients

Clinical & Experimental Allergy, 2011
Summary Background Peroxisome proliferator‐activated receptor gamma coactivator 1 beta (PPARGC1B) is a co‐activator for intracellular receptors such as the estrogen receptor, PPAR, and glucocorticoid receptor, which are involved in asthma development.
S-H, Lee, A-S, Jang, S, Woo Park, J-S, Park, Y K, Kim, S-T, Uh, Y H, Kim, I Y, Chung, B-L, Park, H D, Shin, C-S, Park   +10 more
openaire   +2 more sources

PPARγand PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk

Biomarkers, 2013
Breast cancer (BC) risk has been differentially associated with urinary levels of some phthalate metabolites.To investigate whether PPARγ and PPARGC1B polymorphisms modulate these associations.208 BC cases were age-matched with 220 population controls. Phthalate metabolites were determined by HPLC-MS.
Gabriela A, Martínez-Nava, Ana I, Burguete-García, Lizbeth, López-Carrillo, Raúl U, Hernández-Ramírez, Vicente, Madrid-Marina, Mariano E, Cebrián   +5 more
openaire   +2 more sources

[The analysis of PPARGC1B gene polymorphism in athletes].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2010
The aim of the study was to investigate allelic distribution of the peroxisome proliferator-activated receptor gamma coactivator 1beta gene (PPARGC1B; Ala203Pro polymorphism) in athletes (n = = 1535) and controls (n = 1113), and to find interrelation between genotypes and aerobic performance of athletes.
I I, Akhmetov, D V, Popov, S S, Missina, O L, Vinogradova, V A, Rogozkin   +4 more
openaire   +1 more source

Abstract 5485: Coactivator PPARGC1B Ala203Pro polymorphism is linked with estrogen-related receptor function and breast cancer outcome

Cancer Research, 2015
Abstract Background The estrogen-related receptors (ERRs) are orphan nuclear receptors (NRs) with high sequence similarity to the estrogen receptor (ER). Peroxisome proliferator-activated receptor gamma coactivator-1 beta (PERC) specifically activates ER and ERRs, thus providing a link with breast cancer growth.
Pilar H. Saladores, Reiner Hoppe, Wing-Yee Lo, Sibylle Cocciardi, Ute Hofmann, Ute Hamann, Peter Fasching, Marcus Schmidt, Hiltrud Brauch, Werner Schroth   +9 more
openaire   +1 more source

Putative association of peroxisome proliferator‐activated receptor γ co‐activator 1β (PPARGC1B) polymorphism with Type 2 diabetes mellitus

Diabetic Medicine, 2006
AbstractAims  Peroxisome proliferator‐activated receptor γ co‐activator 1β (PPARGC1B) may play an important role in obesity and Type 2 diabetes mellitus (T2DM). In an effort to identify genetic polymorphisms in potential candidate genes for T2DM, genetic associations of PPARGC1B were examined in a Korean T2DM study.Methods  We have sequenced the ...
K S, Park, H D, Shin, B L, Park, H S, Cheong, Y M, Cho, H K, Lee, J-Y, Lee, J-K, Lee, H Tae, Kim, C-S, Park, B G, Han, K, Kimm, B, Oh   +12 more
openaire   +2 more sources

Analysis of Clinical Indexes and RUNX3 , TBKBP1 , PPARGC1B Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis

Genetic Testing and Molecular Biomarkers, 2014
Background: Ankylosing spondylitis (AS) is a genetically determined disease. Runt-related transcription factor 3 ( RUNX3 ), tumor necrosis factor family member-associated NF-κB activator binding kinase 1 binding protein ( TBKBP1 ...
Jun Liu, Zijian Lian, Yu Xiao, Lewis L. Shi, Wei Chai, Yan Wang   +5 more
openaire   +1 more source