Results 211 to 220 of about 350,201 (281)

ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia. [PDF]

J Bone Miner Res
Narisawa S, Amadeu de Oliveira F, Tokuhara CK, Lira Dos Santos EJ, Fonfria E, Batson J, Cheng Z, Houston A, Foster BL, Millán JL.   +9 more
europepmc   +1 more source

Outpatient treatment of decompensated heart failure: A systematic review and study level meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 761-769, April 2025.
Abstract Patients with acutely decompensated heart failure (ADHF) are usually admitted to hospital for management. There is growing interest in delivering intravenous (IV) diuretic therapy at home, in the community or at hospital day‐care units; the safety and effectiveness of outpatient‐based management (OPM) for ADHF has not been established.
Jameela Bahar, Amna Rahman, Grace W.Y. Wong, Rajiv Sankaranarayanan, Fozia Z. Ahmed, Rebecca Taylor, Ahmet Fuat, Iain Squire, John G.F. Cleland, Gregory Y.H. Lip, James H.P. Gamble, Sundas Masudi, Prince Josiah S. Joseph, Kenneth Y.K. Wong   +13 more
wiley   +1 more source

Gut Microbial Variations Associated With Proton Pump Inhibitor Use in the Boston Puerto Rican Health Study. [PDF]

Pharmacol Res Perspect
Dinesh D, Morgan XC, Kim H, Scott TM, Garelnabi M, Lee JS, Mangano KM, Nguyen LH, Huttenhower C, Tucker KL, Palacios N.   +10 more
europepmc   +1 more source

Virtual PPI toolkit

Virtual toolkit (information material & web-based learning resources) for use in national populations and diverse ...
openaire   +1 more source

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Timing and intensity of proton pump inhibitor exposure hampers overall survival in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors: a retrospective cohort study. [PDF]

Front Immunol
Japelj N, Horvat N, Jazbar J, Kos M, Kapušin VP, Knez L.   +5 more
europepmc   +1 more source

Isolated absence epilepsy associated with a de novo FBXW7 missense variant in the F‐box domain

Epilepsia Open, EarlyView.
Abstract The FBXW7 gene encodes a substrate‐recognition component of the Skp1‐Cul1‐F‐box (SCF) E3 ubiquitin ligase complex, which targets key regulatory proteins for proteasomal degradation. Recently, loss‐of‐function FBXW7 variants have been associated with a novel neurodevelopmental disorder characterized by heterogeneous clinical features.
Anees Muhammad, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi, Francesca Madia, Maria Margherita Mancardi, Stefania Fornarino, Luca Bosisio, Zahra Hoseini Tavassol, Mir Davood Omrani, Federico Zara, Marcello Scala   +10 more
wiley   +1 more source

ILAE dietary treatments task force special report: Maternal ketogenic diet exposure in epilepsy pregnancy registries—A call to action

Epilepsia Open, EarlyView.
Abstract Ketogenic dietary therapies (KDTs) are increasingly used worldwide as a non‐pharmacological treatment for epilepsy, including among people of childbearing potential. In many cases, KDTs allow for the reduction of antiseizure medications (ASMs) and lower drug exposure during pregnancy.
Magnhild Kverneland, Valentina De Giorgis, Laura Healy, Kelly Faltersack, Tanya J. W. McDonald, Marisa Armeno, Mackenzie C. Cervenka, Anita Devlin   +7 more
wiley   +1 more source

Numerical Simulation and Analysis of Heat Transfer Characteristics in Gradient‐Porosity Foam Copper Composite Phase Change Materials

Energy Science &Engineering, EarlyView.
This study investigates the heat transfer characteristics of copper‐foam composite phase change materials with different gradient porosities. Three models with uniform porosity and three models with gradient porosities are developed to examine their effects on temperature distribution and melting behavior. ABSTRACT Phase change materials (PCMs) exhibit
Wei Yang, Chenchen Bao, Guofeng Zhou, Yuxi Qiao, Ruiling Yu, Manfeng Li, Linlin Zhang   +6 more
wiley   +1 more source

Proton Pump Inhibitors and Risk of Chronic Kidney Disease: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Almabruk BA, Alsulami GA, Alzahrani A, Alsulami EA, Badawood AA, Alghanim AS, Alresheedi FF, Alharbi RS, Alghamdi HA.   +8 more
europepmc   +1 more source