Results 121 to 130 of about 7,127 (231)

Identification and comparative analysis of sixteen fungal peptidyl-prolyl cis/trans isomerase repertoires

BMC Genomics, 2006
Background The peptidyl-prolyl cis/trans isomerase (PPIase) class of proteins is present in all known eukaryotes, prokaryotes, and archaea, and it is comprised of three member families that share the ability to catalyze the cis/trans isomerisation of a ...
Pemberton Trevor J
doaj   +1 more source

The cuticle [PDF]

, 2007
The nematode cuticle is an extremely flexible and resilient exoskeleton that permits locomotion via attachment to muscle, confers environmental protection and allows growth by molting.
Johnstone, I. J., Page, A. P.
core   +1 more source

Cj0596 is a periplasmic peptidyl prolyl cis-trans isomerase involved in Campylobacter jejuni motility, invasion, and colonization [PDF]

, 2009
Background Campylobacter jejuni is a gastrointestinal pathogen of humans, but part of the normal flora of poultry, and therefore grows well at the respective body temperatures of 37°C and 42°C. Proteomic studies on temperature regulation in C.
Kimberly M Rathbun, Johanna E Hall, Stuart A Thompson   +2 more
core   +1 more source

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? [PDF]

, 2009
The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than ...
Matthias Sieber, Ria Baumgrass, CB Klee, GR Crabtree, CB Klee, JO Liu, JO Liu, M Morioka, A Rao, E Serfling, PG Hogan, F Macian, J Yang, TD Batiuk, IA Graef, OF Bueno, H Okamura, C Luo, J Zhu, CR Beals, H Okamura, J Liu, J Aramburu, FJ Garcia-Cozar, S Martinez-Martinez, A Rodriguez, H Li, J Roy, B Frantz, T Sugimoto, RE Dolmetsch, H Alzuherri, JA Valdes, L Guo, Q Liu, J Ninomiya-Tsuji, JP Pearl, DL Jones, AL Taylor, MM El-Batawy, C Brandt, F Rusnak, R Sugiura, JF Borel, RY Calne, TE Starzl, T Kino, TE Starzl, J Liu, SL Schreiber, S Barik, CB Kang, JP Griffith, CR Kissinger, Q Huai, L Jin, SK Swanson, M Yin, RE Handschumacher, JJ Siekierka, MW Harding, K Kalli, Y Aoki, NM Steffan, E Oetjen, R Marienfeld, S Meyer, P Nickel, M Naesens, A Kiani, Y Zhang, PL Durette, NH Sigal, PA Nelson, R Baumgrass, JD Aebi, L Aspeslet, T Birsan, WP Maksymowych, P Naidoo, FJ Dumont, A Klettner, J Liu, M Grassberger, LB Peterson, FJ Dumont, SL Schreiber, AW Thomson, JM Campistol, TL Born, BL Martin, SG Stewart, DC Weiser, A Enz, KL Fakata, H Wang, H Lei, S Lee, M Humar, M Humar, T Loop, C Correa-Sales, Y Baba, Y Baba, NJ Carruthers, WB Xu, B Weissenmayer, MS Gomez, BZ Yu, RC Adlakha, A Gualberto, GM Brill, MC Mulero, AA Borisy, M Sieber, MH Roehrl, S Kang, SW Djuric, Y Chen, JM Trevillyan, J Ishikawa, C Zitt, R Takezawa, T Yoshino, K Ohga, N Steinckwich, T Birsan, LM Nilsson, RI Jabr, R Lindstedt, G Mistrello, S Campo, ED Hogestatt, FJ Caballero, J Roman, E Bailon, M Aceves, P Proksch, SJ O'Keefe, L Vega Lde, K Mousavizadeh, N Venkatesh, Y Baine, SD Yang, F Rusnak, C Aussel, EJ Jung, N Marquez, S Ansorge, K Natarajan, S Kuromitsu, WF Michne, CM Murray, NS Burres, SI Lee, N Marquez, HZ Jin, PV Kiem, NT Dat, NT Dat, XF Cai, XF Cai, XF Cai, NT Dat, IS Lee, JK Sagoo, Y Hashimoto, BA Perrino, BA Perrino, H Terada, SZ Husain, S Feske, J Aramburu, H Noguchi, ML Dell'Acqua, MM Lai, L Sun, CD Harris, B Chan, A Aubareda, S Martinez-Martinez, S Mehta, S Park, J Liu, H Jang, TJ Kingsbury, RB Vega, M Boncristiano, B Gebert, MS Sundrud, X Sewald, JE Miskin, AG Granja, S Matsuda, AG Granja, JE Miskin, JH Tatlock, C Bialojan, DA Fruman, PJ Sinclair, R Baumgrass   +200 more
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Non-Catalytic Participation of the Pin1 Peptidyl-Prolyl Isomerase Domain in Target Binding

Frontiers in Physiology, 2013
Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways.
Brendan Tooke Innes, Melanie L. Bailey, Christopher J Brandl, Brian H. Shilton, David William Litchfield   +4 more
doaj   +1 more source

Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed α-helix [PDF]

, 2014
The macrophage infectivity potentiator protein from Trypanosoma cruzi (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion.
Coll, Miquel, Fernández-Carazo, Rafael, Gomis-Rüth, F. Xavier, Gomis-Rüth, F. Xavier, González, Antonio L., González-Rey, Elena, Macedo-Ribeiro, Sandra, Pereira, Pedro José Barbosa, Vega, María Cristina   +8 more
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Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis

BMC Evolutionary Biology, 2006
Background Recently, HEN1 protein from Arabidopsis thaliana was discovered as an essential enzyme in plant microRNA (miRNA) biogenesis. HEN1 transfers a methyl group from S-adenosylmethionine to the 2'-OH or 3'-OH group of the last nucleotide of miRNA ...
Obarska Agnieszka, Tkaczuk Karolina L, Bujnicki Janusz M   +2 more
doaj   +1 more source

Effects of rapamycin on cultured hepatocyte proliferation and gene expression [PDF]

, 1992
Rapamycin, a potent immunosuppressive drug that disrupts normal signal‐transduction processes, inhibited hepatocyte proliferation without evidence of inherent cytotoxicity in rat hepatocytes cultured in conventional medium or in a medium enriched with ...
Azzarone, A, Carr, BI, Carrieri, G, Francavilla, A, Starzl, TE, Zeng, Q‐   +5 more
core   +1 more source

The Prolyl Isomerase Pin1 in Breast Development and Cancer [PDF]

, 2011
The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer.
Liou, Yih-Cherng, Lu, Kun Ping, Ryo, Akihide, Wulf, Gerburg Maria   +3 more
core  

Screening for PPIase Pin1 Inhibitors

KAGAKU TO SEIBUTSU, 2011
Tadashi MORI, Takafumi UCHIDA
openaire   +2 more sources