Results 1 to 10 of about 9,080 (142)
Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo [PDF]
PharmaceuticsBackground: The peptidyl–prolyl cis–trans isomerase PIN1 regulates multiple oncogenic and tumor-suppressive pathways and is frequently overexpressed in human cancers.
Yuying Ma +10 more
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Neurobiology of Disease, 2015 The unique proline isomerase Pin1 is pivotal for protecting against age-dependent neurodegeneration in Alzheimer's disease (AD), with its inhibition providing a molecular link between tangle and plaque pathologies.
Tae Ho Lee +2 more
exaly +3 more sources
Circulating Pin1 Levels in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Case‐Control Study [PDF]
Pulmonary CirculationChronic thromboembolic pulmonary hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE), yet its underlying mechanisms remain poorly understood.
Lynn Willems +11 more
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Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies
Neurobiology of Disease, 2003 Pin1, a peptidyl-prolyl isomerase binds to mitotic serine or threonine phosphoproteins. In Alzheimer's disease (AD) evidence points to the reactivation of mitosis in vulnerable neurons.
Dennis W Dickson, Peter Davies
exaly +3 more sources
Effects of Pin1 on Proliferation and Apoptosis of HepG2 Cells Under Endoplasmic Reticulum Stress
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the expression of Pin1 protein in HepG2 cells under endoplasmic reticulum stress (ERS) and its effect on cell proliferation and apoptosis. Methods The THLE3 cells were treated with tunicamycin (TM) (TM group) or DMSO (DMSO group)
JIANG Mingting, HUANG Jin, ZHENG Shuping
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陆军军医大学学报, 2022 Objective To knock out PIN1 gene of porcine fetal fibroblasts (PFFs) by clustered regular interval short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system in order to establish PIN1 knockout porcine fetal fibroblast cell lines ...
WANG Wanyi +5 more
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Frontiers in Cell and Developmental Biology, 2022 More than 20 years since its discovery, our understanding of Pin1 function in various diseases continues to improve. Pin1 plays a crucial role in pathogenesis and has been implicated in metabolic disorders, cardiovascular diseases, inflammatory diseases,
Yew Mun Lee +3 more
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Inhibition of the PIN1-NRF2/GPX4 axis imparts sensitivity to cisplatin in cervical cancer cells
Acta Biochimica et Biophysica Sinica, 2022 The incidence of cervical cancer (CC) ranks the fourth in female malignant tumors globally. Chemoresistance is one of the main causes of treatment failure in advanced recurrent CC. Prolyl isomerase 1 (PIN1) is overexpressed in a variety of tumors, and is
Zhang Zheng +3 more
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Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma. [PDF]
PLoS ONE, 2016 BACKGROUND:Nasopharyngeal carcinoma (NPC) is a peculiar Epstein Barr virus (EBV)-associated malignancy that is prevalent in South-East Asia. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) isomerizes specific phosphorylated amino acid ...
Meng Xu +5 more
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Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1
Frontiers in Cell and Developmental Biology, 2020 The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.
Dongmei Chen, Long Wang, Tae Ho Lee
doaj +1 more source