Results 21 to 30 of about 2,931 (173)
Cell Reports, 2019 Summary: Non-shivering thermogenesis in adipocytes provides defense against low temperatures and obesity development, but the underlying regulatory mechanism remains to be fully clarified.
Yusuke Nakatsu +24 more
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Hyperglycemia induces gastric carcinoma proliferation and migration via the Pin1/BRD4 pathway
Cell Death Discovery, 2022 Diabetes is a potential risk factor for gastric cancer (GC). Pin1, a peptidyl–prolyl cis/trans isomerase, promotes GC cell proliferation and migration.
Jianjian Yu +8 more
doaj +1 more source
Pin1: A molecular orchestrator in the heart [PDF]
Trends in Cardiovascular Medicine, 2014 Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes.
Nirmala, Hariharan, Mark A, Sussman
openaire +2 more sources
Pin1 and JNK1 cooperatively modulate TAp63γ [PDF]
FEBS Open Bio, 2021 Thep63gene encodes at least 10 isoforms, which can be classified into TA and ∆N isotypes (TAp63 and ∆Np63 proteins) according to their differences at the N termini. TAp63γ is an important transcription factor. We previously reported that peptidyl‐prolyl isomerase (PPI) Pin1 directly binds to TAp63γ protein and identified that serine 12 (S12) in the ...
Xueying Fan +6 more
openaire +3 more sources
European Journal of Inflammation, 2020 The aim of this study was to investigate the predictive value of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with C-reactive protein (CRP) and white blood cell (WBC) count for community-acquired pneumonia (CAP) in infants. A total of 84
Heng Xue +8 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Here, we demonstrate that the peptidyl-prolyl cis/trans isomerase Pin1 interacts noncovalently with the hepatitis B virus (HBV) core particle through phosphorylated serine/threonine-proline (pS/TP) motifs in the carboxyl-terminal domain (CTD) but not ...
Hyeonjoong Kwon +17 more
doaj +1 more source
Prolyl isomerase Pin1 in cancer [PDF]
Cell Research, 2014 Proline-directed phosphorylation is a posttranslational modification that is instrumental in regulating signaling from the plasma membrane to the nucleus, and its dysregulation contributes to cancer development. Protein interacting with never in mitosis A1 (Pin1), which is overexpressed in many types of cancer, isomerizes specific phosphorylated Ser ...
Zhimin, Lu, Tony, Hunter
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Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]
International Journal of Medical Arts, 2021 Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah +2 more
doaj +1 more source
Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy
Biomedicines, 2021 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in
Hsiang-Hao Chuang +6 more
doaj +1 more source
Pathology & Oncology Research, 2013 Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) plays a key role in a number of diseases including cancer and Alzheimer disease. Previous studies have identified a wide range of phosphoproteins as Pin1 substrates. Related pathways were analyzed separately.
Guo-Liang, Huang +6 more
openaire +2 more sources