Results 21 to 30 of about 11,541 (227)
Understanding the role of PIN1 in hepatocellular carcinoma [PDF]
World Journal of Gastroenterology, 2016 PIN1 is a peptidyl-prolyl cis/trans isomerase that binds and catalyses isomerization of the specific motif comprising a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) in proteins. PIN1 can therefore induce conformational and functional changes of its interacting proteins that are regulated by proline-directed serine ...
Tse, EWC, Cheng, CW, Leong, KW
openaire +6 more sources
The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. [PDF]
PLoS ONE, 2012 Pin1 has previously been described to regulate cells that participate in both innate and adaptive immunity. Thus far, however, no role for Pin1 has been described in modulating conventional dendritic cells, innate antigen presenting cells that potently ...
Theresa J Barberi +4 more
doaj +1 more source
Pin1-KO ASC- transfected with Lentiviral Pin1 cDNA. [PDF]
, 2016 Transfection was verified by observing GFP with fluorescence microscope and the western blot analysis of Pin1 and α-tubulin (1st: anti-h/m Pin1 antibody (Santa Cruz), anti-α-tubulin antibody (SIGMA), 2nd anti-mouse IgG HRP-linked antibody (Cell Signaling)
Chiyoko Uchida (230780) +4 more
core +1 more source
Cell Reports, 2019 Summary: Non-shivering thermogenesis in adipocytes provides defense against low temperatures and obesity development, but the underlying regulatory mechanism remains to be fully clarified.
Yusuke Nakatsu +24 more
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Hyperglycemia induces gastric carcinoma proliferation and migration via the Pin1/BRD4 pathway
Cell Death Discovery, 2022 Diabetes is a potential risk factor for gastric cancer (GC). Pin1, a peptidyl–prolyl cis/trans isomerase, promotes GC cell proliferation and migration.
Jianjian Yu +8 more
doaj +1 more source
Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]
International Journal of Medical Arts, 2021 Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah +2 more
doaj +1 more source
Targeting Pin1 for Modulation of Cell Motility and Cancer Therapy
Biomedicines, 2021 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in
Hsiang-Hao Chuang +6 more
doaj +1 more source
European Journal of Inflammation, 2020 The aim of this study was to investigate the predictive value of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with C-reactive protein (CRP) and white blood cell (WBC) count for community-acquired pneumonia (CAP) in infants. A total of 84
Heng Xue +8 more
doaj +1 more source
Pin1: A molecular orchestrator in the heart [PDF]
Trends in Cardiovascular Medicine, 2014 Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes.
Nirmala, Hariharan, Mark A, Sussman
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Pin1 and JNK1 cooperatively modulate TAp63γ [PDF]
FEBS Open Bio, 2021 Thep63gene encodes at least 10 isoforms, which can be classified into TA and ∆N isotypes (TAp63 and ∆Np63 proteins) according to their differences at the N termini. TAp63γ is an important transcription factor. We previously reported that peptidyl‐prolyl isomerase (PPI) Pin1 directly binds to TAp63γ protein and identified that serine 12 (S12) in the ...
Xueying Fan +6 more
openaire +3 more sources