Results 1 to 10 of about 18,044 (216)
Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea [PDF]
Frontiers in Microbiology, 2021 Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of ...
Anchal, Vineeta Kaushik, Manisha Goel
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The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors [PDF]
Frontiers in Cell and Developmental Biology, 2023 The peptidyl prolyl cis-trans isomerase Pin1 plays vital roles in diverse cellular processes and pathological conditions. NeuroD is a differentiation and survival factor for a subset of neurons and pancreatic endocrine cells.
Liqun Zhao +7 more
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Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1 [PDF]
Frontiers in Cell and Developmental Biology, 2020 The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.
Dongmei Chen, Long Wang, Tae Ho Lee
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Roles of peptidyl prolyl isomerase Pin1 in viral propagation [PDF]
Frontiers in Cell and Developmental Biology, 2022 Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer ...
Machi Kanna +7 more
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Prolyl Isomerase, Pin1, Controls Meiotic Progression in Mouse Oocytes [PDF]
Cells, 2022 During meiotic maturation, accurate progression of meiosis is ensured by multiple protein kinases and by signal transduction pathways they are involved in. However, the mechanisms regulating the functions of phosphorylated proteins are unclear.
Yumi Hoshino, Takafumi Uchida
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Prolyl-Isomerase Pin1 Controls Key fMLP-Induced Neutrophil Functions [PDF]
Biomedicines, 2021 Neutrophils are key cells of the innate immune and inflammatory responses. They are the first blood cells to migrate to the infection site where they release high amounts of reactive oxygen species (ROS) and several peptides and enzymes required for ...
Samia Bedouhene +6 more
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Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance [PDF]
Frontiers in Cell and Developmental Biology, 2020 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is an evolutionally conserved and unique enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif and, subsequently ...
Wenchen Pu, Yuanyuan Zheng, Yong Peng
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The prolyl isomerase FKBP11 is a secretory translocon accessory factor. [PDF]
Mol Biol CellEukaryotic cells encode thousands of secretory and membrane proteins, many of which are cotranslationally translocated into the endoplasmic reticulum (ER). Nascent polypeptides entering the ER encounter a network of molecular chaperones and enzymes that facilitate their folding. A rate-limiting step for some proteins is the trans-to- cis isomerization
DiGuilio A +10 more
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Frontiers in Genetics, 2021 Objective: The aim of the present study was to construct a prognostic model based on the peptidyl prolyl cis–trans isomerase gene signature and explore the prognostic value of this model in patients with hepatocellular carcinoma.Methods: The ...
Huadi Shi +6 more
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Cells, 2022 Antibodies are central effectors of the adaptive immune response, widespread used therapeutics, but also potentially disease-causing biomolecules. Antibody folding catalysts in the plasma cell are incompletely defined. Idiopathic pulmonary fibrosis (IPF)
Stefan Preisendörfer +23 more
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