Results 11 to 20 of about 18,044 (216)
Molecules, 2008 The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively.
Gunter Fischer +4 more
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Effect of MF3 (peptidyl-prolyl cis/trans isomerase) protein from Pseudomonas fluorescens on ex vitro adaptation and post-adaptation of hardy kiwi (Actinidia arguta Planch. ex Miq.) plants [PDF]
BIO Web of ConferencesThe effect of bacterial protein (peptidyl-prolyl cis/trans isomerase) in different concentrations on ex vitro adaptation and post-adaptation of Actinidia arguta Planch. ex Miq. plants of cultivar Geneva was investigated. The results indicating the growth-
Sergeeva Kseniia +2 more
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Peptidyl Prolyl Isomerase A Modulates the Liquid-Liquid Phase Separation of Proline-Rich IDPs. [PDF]
J Am Chem Soc, 2022 [Image: see text] Liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) and the action of molecular chaperones are tightly connected. An important class of molecular chaperones are peptidyl prolyl isomerases, which enhance the
Babu M +3 more
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Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons [PDF]
Cell Reports, 2015 Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood.
Martin Balastik +15 more
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Dissecting the functional behavior of the differentially phosphorylated prolyl isomerase, Pin1. [PDF]
Protein SciProtein post‐translational modifications (PTMs) play an intricate role in a diverse range of cellular processes creating a complex PTM code that governs cell homeostasis.
Kay DF +4 more
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Prolyl isomerase Pin1 in cancer [PDF]
Cell Research, 2014 Proline-directed phosphorylation is a posttranslational modification that is instrumental in regulating signaling from the plasma membrane to the nucleus, and its dysregulation contributes to cancer development. Protein interacting with never in mitosis A1 (Pin1), which is overexpressed in many types of cancer, isomerizes specific phosphorylated Ser ...
Zhimin, Lu, Tony, Hunter
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Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression. [PDF]
PLoS ONE, 2016 Growth factor receptor bound protein-7 (Grb7) is a multi-domain adaptor protein that is co-opted by numerous tyrosine kinases involved in various cellular signaling and functions. The molecular mechanisms underlying the regulation of Grb7 remain unclear.
Yu-Ling Tai +9 more
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iScience, 2020 Summary: Prolactin (PRL) and its receptor (PRLr) play important roles in the pathogenesis of breast cancer. Cyclophilin A (CypA) is a cis-trans peptidyl-prolyl isomerase (PPI) that is constitutively associated with the PRLr and facilitates the activation
Shawn Hakim +3 more
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Ligand-specific conformational change drives interdomain allostery in Pin1
Nature Communications, 2022 Born et al. describe interdomain allostery in the two domain peptidyl-prolyl isomerase Pin1 upon binding of two ligands. These ligands couple population shifts of extended and compact states to changes in the catalytic site of Pin1.
Alexandra Born +6 more
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Communications Biology, 2021 Leung et al. find that the peptidyl-prolyl isomerase Pin1 targets the intrinsically disordered N-terminal domain of the androgen receptor (AR). They show that combining Pin1 inhibition with ralaniten compounds that bind to the AR N-terminal domain has ...
Jacky K. Leung +5 more
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