Results 41 to 50 of about 18,044 (216)

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth

Cell Reports, 2020
Summary: Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomerase (
Giorgio Ramadori, Rafael M. Ioris, Zoltan Villanyi, Raquel Firnkes, Olesya O. Panasenko, George Allen, Georgia Konstantinidou, Ebru Aras, Xavier Brenachot, Tommasina Biscotti, Anne Charollais, Michele Luchetti, Fedor Bezrukov, Alfredo Santinelli, Muntaha Samad, Pierre Baldi, Martine A. Collart, Roberto Coppari   +17 more
doaj   +1 more source

Bacterial Chaperone Domain Insertions Convert Human FKBP12 into an Excellent Protein-Folding Catalyst—A Structural and Functional Analysis

Molecules
Many folding enzymes use separate domains for the binding of substrate proteins and for the catalysis of slow folding reactions such as prolyl isomerization. FKBP12 is a small prolyl isomerase without a chaperone domain.
Gabriel Žoldák, Thomas A. Knappe, Anne-Juliane Geitner, Christian Scholz, Holger Dobbek, Franz X. Schmid, Roman P. Jakob   +6 more
doaj   +1 more source

Rescue of conformational dynamics in enzyme catalysis by directed evolution

Nature Communications, 2018
A key challenge in the field of protein design and evolution is to understand the mechanisms by which directed evolution is improving enzymes. Here the authors combine different biophysical methods and give mechanistic insights into how directed ...
Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James S. Fraser   +7 more
doaj   +1 more source

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability [PDF]

, 2007
The heterodimeric hypoxia-inducible transcription factors (HIFs) are central regulators of the response to low oxygenation. HIF-alpha subunits are constitutively expressed but rapidly degraded under normoxic conditions.
Camenisch, G., Edlich, Frank, Stiehl, Daniel P., Barth, Sandra, Wirthner, R., Katschinski, D. M., Nytko, Katarzyna J., Edlich, F, Nesper, J., Edlich, F., Wirthner, R, Katschinski, Doerthe Magdalena, Stiehl, D. P., Camenisch, Gieri, Wenger, R. H., Stiehl, D P, Wirthner, Renato, Nytko, K. J., Nesper, J, Barth, S., Katschinski, D M, Wenger, Roland H., Hasgall, P. A., Nytko, K J, Camenisch, G, Hasgall, P A, Hasgall, Philippe A., Barth, S, Nesper, Jutta, Wenger, R H   +29 more
core   +1 more source

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. [PDF]

PLoS Biology, 2010
Peptidyl-prolyl isomerases catalyze the conversion between cis and trans isomers of proline. The cyclophilin family of peptidyl-prolyl isomerases is well known for being the target of the immunosuppressive drug cyclosporin, used to combat organ ...
Tara L Davis, John R Walker, Valérie Campagna-Slater, Patrick J Finerty, Ragika Paramanathan, Galina Bernstein, Farrell MacKenzie, Wolfram Tempel, Hui Ouyang, Wen Hwa Lee, Elan Z Eisenmesser, Sirano Dhe-Paganon   +11 more
doaj   +1 more source

Proteasomal Degradation of Human Peptidyl Prolyl Isomerase Pin1-pointing Phospho Bcl2 toward Dephosphorylation

Neoplasia: An International Journal for Oncology Research, 2002
Microtubule inhibitor-induced Bcl2 phosphorylation is detrimental to its antiapoptotic function. Phosphorylation of Bcl2 predominantly occurs on two serine residues (70 and 87) in cells arrested at G2-M phase by microtubule disarraying agents.
Aruna Basu, Madhusudan Das, Suparna Qanungo, Xue-Jun Fan, Garrett DuBois, Subrata Haldar   +5 more
doaj   +1 more source

Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis

Nature Communications, 2021
The most frequent cause of familial Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are hexanucleotide repeat expansions in the non-coding region of the C9ORF72 gene that are translated into five dipeptide repeat (DPR) proteins ...
Maria Babu, Filippo Favretto, Alain Ibáñez de Opakua, Marija Rankovic, Stefan Becker, Markus Zweckstetter   +5 more
doaj   +1 more source

Prolyl isomerase pin1 protects mice from endotoxin shock.

PLoS ONE, 2011
BackgroundProlyl isomerase Pin1 may be involved in innate immunity against microbial infection, but the mechanism how Pin1 controls the innate immunity is poorly understood.Methodology/principal findingsInjection of lipopolysaccharide (LPS) into the mice
Hirotada Akiyama, Takuma Misawa, Masao Ono, Chiyoko Uchida, Takafumi Uchida   +4 more
doaj   +1 more source

Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells

Cell Reports, 2018
Summary: The SRC-family kinase LYN is highly expressed in triple-negative/basal-like breast cancer (TNBC) and in the cell of origin of these tumors, c-KIT-positive luminal progenitors.
Giusy Tornillo, Catherine Knowlson, Howard Kendrick, Joe Cooke, Hasan Mirza, Iskander Aurrekoetxea-Rodríguez, Maria d.M. Vivanco, Niamh E. Buckley, Anita Grigoriadis, Matthew J. Smalley   +9 more
doaj   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source