Phosphate-Induced Renal Fibrosis Requires the Prolyl Isomerase Pin1. [PDF]
PLoS ONE, 2016 Tubulo-interstitial fibrosis is a common, destructive endpoint for a variety of kidney diseases. Fibrosis is well correlated with the loss of kidney function in both humans and rodents.
Zhong-Jian Shen +4 more
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Structural and Functional Insights into Human Nuclear Cyclophilins
Biomolecules, 2018 The peptidyl prolyl isomerases (PPI) of the cyclophilin type are distributed throughout human cells, including eight found solely in the nucleus. Nuclear cyclophilins are involved in complexes that regulate chromatin modification, transcription, and pre ...
Caroline Rajiv, Tara L. Davis
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Protein disulfide isomerase activity is essential for viability and extracellular matrix formation in the nematode Caenorhabditis elegans. [PDF]
, 2007 Protein disulfide isomerase (PDI) is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum.
Page, Antony P. +5 more
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Nature Communications, 2022 Lower activity of MATα1, which catalyzes the synthesis of the methyl donor S-adenosylmethionine, and mitochondrial dysfunction occur in alcohol-associated liver disease (ALD).
Lucía Barbier-Torres +21 more
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Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies [PDF]
Frontiers in Pharmacology, 2019 Editorial on the Research Topic: Peptidyl-prolyl Isomerases in Human ...
Tiziano Tuccinardi +2 more
openaire +3 more sources
Dimeric structure of the bacterial extracellular foldase PrsA [PDF]
, 2015 Secretion of proteins into the membrane-cell wall space is essential for cell wall biosynthesis and pathogenicity in Gram-positive bacteria. Folding and maturation of many secreted proteins depend on a single extracellular foldase, the PrsA protein. PrsA
Schmidpeter, Philipp A. M. +7 more
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Loss of secretory pathway FK506-binding proteins results in cold-sensitive lethality in caenorhabditis elegans [PDF]
, 2007 The FK506-binding proteins (FKBs) represent ubiquitous enzymes that catalyse the rate-limiting peptidyl prolyl cis-trans isomerization step in protein folding. The nematode <i>Caenorhabditis elegans</i> has eight FKBs, three of which (FKB-3, -
Page, Antony P. +7 more
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Prolyl 4-hydroxlase activity is essential for development and cuticle formation in the human infective parasitic nematode Brugia malayi [PDF]
, 2013 Collagen prolyl 4-hydroxylases (C-P4H) are required for formation of extracellular matrices in higher eukaryotes. These enzymes convert proline residues within the repeat regions of collagen polypeptides to 4-hydroxyproline, a modification essential for ...
Page, A. +3 more
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An Alternative Pin1 Binding and Isomerization Site in the N-Terminus Domain of PSD-95
Frontiers in Molecular Neuroscience, 2020 Phosphorylation-dependent peptidyl-prolyl cis-trans isomerization plays key roles in cell cycle progression, the pathogenesis of cancer, and age-related neurodegeneration.
Jary Y. Delgado
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Nature Communications, 2022 Pharmacological inhibition of the prolyl isomerase PIN1, highly expressed in cancer cells and cancer associated fibroblasts (CAF), has been proposed for cancer therapy. Here the authors report the design of a DNA-barcoded micellular system functionalized
Jiaye Liu +25 more
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