Results 31 to 40 of about 18,044 (216)
Cells, 2023 Cyclophilin E (CypE) belongs to the cyclophilin family and exhibits peptidyl-prolyl cis-trans isomerase (PPIase) activity. It participates in various biological processes through the regulation of peptidyl-prolyl isomerization. However, the specific role
Meiyu Piao +5 more
doaj +1 more source
The prolyl isomerase Pin1 in breast development and cancer [PDF]
Breast Cancer Research, 2003 The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin D1 and transformation of breast epithelial cells in collaboration ...
Wulf, Gerburg +3 more
openaire +3 more sources
Structural and Functional Characterization of a Novel Family of Cyclophilins, the AquaCyps [PDF]
, 2016 Cyclophilins are ubiquitous cis-trans-prolyl isomerases (PPIases) found in all kingdoms of life. Here, we identify a novel family of cyclophilins, termed AquaCyps, which specifically occurs in marine Alphaproteobacteria, but not in related terrestric ...
Timm Maier +14 more
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Prolyl isomerases catalyze antibody folding in vitro [PDF]
Protein Science, 1993 AbstractSome slow‐folding phases in the in vitro refolding of proteins originate from the isomerization of prolyl‐peptide bonds, which can be accelerated by a class of enzymes called prolyl isomerases (PPIs). We used the in vitro folding of an antibody Fab fragment as a model system to study the effect of PPI on a folding reaction that is only ...
H, Lilie +3 more
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BCR‐ABL enhances the prolyl isomerase activity of Pin 1 by interacting with DAPK1 in ph+ ALL
Cancer Medicine, 2018 Philadelphia chromosome (Ph)/BCR‐ABL‐positive (ph+) ALL is the most common genetic abnormality associated with ALL and has been shown to confer the worst prognosis to both children and adults.
Wen‐bin Cao +12 more
doaj +1 more source
Prolyl Isomerases and Nuclear Function [PDF]
Cell, 1998 The c-Myb/Cyp40 interaction raises the question of whether other transcription factors are regulated by PPIases. The only other example of a transcription factor that may be regulated by PPIase action is the zinc finger protein YY1, which interacts with CypA and FKBP12 (Yang et al. 1995xYang, W.M, Inouye, C.J, and Seto, E. J. Biol. Chem.
openaire +2 more sources
Basic surface features of nuclear FKBPs facilitate chromatin binding
Scientific Reports, 2017 The nucleoplasmin family of histone chaperones is identified by a pentamer-forming domain and multiple acidic tracts that mediate histone binding and chaperone activity.
Andrew Leung +10 more
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Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury
Cellular Physiology and Biochemistry, 2018 Background/Aims: Peptidyl-prolyl cis-trans isomerase FKBP25 is a member of the FK506-binding proteins family which has peptidyl-prolyl cis/trans isomerase domain. The biological function and pathophysiologic role of FKBP25 remain elusive.
Quan Jiang +9 more
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Catalytic Antibodies with Peptidyl−Prolyl Cis−Trans Isomerase Activity
, 2016 Catalytic Antibodies with Peptidyl−Prolyl Cis−Trans Isomerase ...
Chih-Hung L. Lo (2995959) +5 more
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Mapping of the ligand-binding site on the b ' domain of human PDI: interaction with peptide ligands and the x-linker region [PDF]
, 2009 PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four thioredoxin-like domains, of which two contain redox-active catalytic sites (a and a'), and two ...
Freedman, R. B. +15 more
core +1 more source