Results 41 to 50 of about 11,541 (227)
, 2019 Overexpression of PIN1 induces the expression of PTOV1, which suggest that PIN1 might be the upstream protein which regulates the expression of PTOV1. Both the gene cooperatively share MAPK pathway including the expression of ERK, C-Jun and the master ...
Shibendra Kumar Lal Karna (6693995) +3 more
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Pin1 interacts with Grb7. [PDF]
, 2016 (A) pGADT7-Pin1 was co-transformed with pGBTK7 (Mock) or pGBTK7-Grb7 into Saccharomyces cerevisiae strain AH109 and was cultured under a SD/-Ade/-His/-Leu/-Trp selective condition.
Hsinyu Lee (149656) +9 more
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Frontiers in Pharmacology, 2018 Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse ...
Taiki Shimizu +4 more
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Pin1 reduces Grb7 protein stability. [PDF]
, 2016 (A) Cell lysates from shLuc- or shPin1-infected (shPin1 #1 or shPin1 #2) A431 cells were collected and subjected to Western blotting with anti-Pin1, anti-Grb7, or anti-Cyclin D1 antibody to examine the protein expression of the indicated molecules.
Hsinyu Lee (149656) +9 more
core +1 more source
The regulatory role of Pin1 in neuronal death
Neural Regeneration Research, 2023 Regulated cell death predominantly involves apoptosis, autophagy, and regulated necrosis. It is vital that we understand how key regulatory signals can control the process of cell death. Pin1 is a cis-trans isomerase that catalyzes the isomerization of phosphorylated serine or threonine-proline motifs of a protein, thereby acting as a crucial molecular
Wang, Shu-Chao, Hu, Xi-Min, Xiong, Kun
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Phylogeny and molecular evolution analysis of PIN-FORMED 1 in angiosperm.
PLoS ONE, 2014 PIN-FORMED 1 (PIN1) is an important secondary transporter and determines the direction of intercellular auxin flow. As PIN1 performs the conserved function of auxin transport, it is expected that the sequence and structure of PIN1 is conserved. Therefore,
Pengkai Wang +8 more
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Frontiers in Bioscience-Landmark, 2023 Background: The stemness characteristics of cancer cells, such as self-renewal and tumorigenicity, are considered to be responsible, in part, for tumor metastasis.
Chendan Zou +10 more
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Pin1 Flips Alzheimer’s Switch [PDF]
ACS Chemical Biology, 2006 The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.
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A bibliometric analysis of PIN1 and cell death
Frontiers in Cell and Developmental Biology, 2022 Background: Regulation of cell death plays a key role in numerous diseases. As a proline isomerase, prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is important for the regulation of signaling pathways. An in-depth understanding of how Pin1 participates in the process of cell death, which affects the occurrence and development of diseases, will ...
Jia-Heng Zhang +6 more
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Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma
Molecular Oncology, 2011 Pin1 specifically recognizes and catalyzes the cis‐trans isomerization of phosphorylated‐Ser/Thr‐Pro bonds, which modulate the stability, localization, and function of numerous Pin1 targets involved in tumor progression.
Brian L. Teng +4 more
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