Results 41 to 50 of about 2,931 (173)

Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma

Molecular Oncology, 2011
Pin1 specifically recognizes and catalyzes the cis‐trans isomerization of phosphorylated‐Ser/Thr‐Pro bonds, which modulate the stability, localization, and function of numerous Pin1 targets involved in tumor progression.
Brian L. Teng, Kathryn E. Hacker, Shufen Chen, Anthony R. Means, W. Kimryn Rathmell   +4 more
doaj   +1 more source

The prolyl isomerase pin1 regulates mRNA levels of genes with short half-lives by targeting specific RNA binding proteins.

PLoS ONE, 2014
The peptidyl-prolyl isomerase Pin1 is over-expressed in several cancer tissues is a potential prognostic marker in prostate cancer, and Pin1 ablation can suppress tumorigenesis in breast and prostate cancers.
Nithya Krishnan, Mark A Titus, Roopa Thapar   +2 more
doaj   +1 more source

Juglone Inhibits Tumor Metastasis by Regulating Stemness Characteristics and the Epithelial-to-Mesenchymal Transition in Cancer Cells both in Vitro and in Vivo

Frontiers in Bioscience-Landmark, 2023
Background: The stemness characteristics of cancer cells, such as self-renewal and tumorigenicity, are considered to be responsible, in part, for tumor metastasis.
Chendan Zou, Yuan Yu, Hefei Wang, Cedric Matunda, Shuang Ding, Linlin Wang, Xianwei Chen, Yunting Le, Jianfeng Jin, Xu Gao, Chaoxia Zou   +10 more
doaj   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

Regulation of PRDX1 peroxidase activity by Pin1 [PDF]

Cell Cycle, 2013
Pin1 isomerizes the phosphorylated Ser/Thr-Pro peptide bonds and regulates the functions of its binding proteins by inducing conformational changes. Involvement of Pin1 in the aging process has been suggested based on the phenotype of Pin1-knockout mice and its interaction with lifespan regulator protein, p66 (Shc) .
Chu, K.L., Lew, Q.J., Rajasegaran, V., Kung, J.T., Zheng, L., Yang, Q., Shaw, R., Cheong, N., Liou, Y.-C., Chao, S.-H.   +9 more
openaire   +2 more sources

Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6 [PDF]

, 2005
The ETV6 gene is involved in many chromosomal translocations forming different fusion genes in both myeloid and lymphoid leukemias as well as in some solid tumors.
Zhang, Chang-Dong
core  

Pin1-induced cis/trans isomerization of lamin A/C.

, 2016
(A-B) NMR spectroscopy of lamin A/C peptides in the presence or absence of Pin1. Superimposed expanded HN-HN regions of the 2D 1H-1H NOESY spectra are depicted for phosphorylated and unphosphorylated versions of a lamin A/C peptide comprising amino acids
Torgils Fossen (1632481), Hanife Bahsi (3073302), Anselm H. C. Horn (440109), Heinrich Sticht (173676), Corina Hutterer (3073305), Jens Milbradt (571373), Eric Sonntag (3073311), Sabrina Wagner (3073308), Benedikt B. Kaufer (341018), Manfred Marschall (571374), Yasuko Mori (668955)   +10 more
core   +1 more source

Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1

Frontiers in Oncology, 2018
Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue. Pin1 is unique and only catalyzes the phosphorylated Serine/Threonine-Proline (S/
Yew Mun Lee, Yih-Cherng Liou
doaj   +1 more source

Non‐Uniform Space‐Time‐Coding Modulation for Low‐Complexity Diagnostics of Reconfigurable Intelligent Surfaces

Advanced Electronic Materials, EarlyView.
A diagnostic method for reconfigurable intelligent surfaces (RIS) based on non‐uniform space‐time‐coding modulation is presented. Fault localization is achieved via amplitude‐only spectral measurements, eliminating the need for complex signal processing. A one‐to‐one mapping between harmonic components and RIS elements enables accurate detection.
Xiao Qing Chen, Lei Zhang, Yi Ning Zheng, Bing Bing Zhu, Marco Rossi, Giuseppe Castaldi, Shuo Liu, Vincenzo Galdi, Tie Jun Cui   +8 more
wiley   +1 more source

The role of the master cancer regulator Pin1 in the development and treatment of cancer

Frontiers in Cell and Developmental Biology
This review examines the complex role of Pin1 in the development and treatment of cancer. Pin1 is the only peptidyl–prolyl isomerase (PPIase) that can recognize and isomerize phosphorylated Ser/Thr-Pro peptide bonds. Pin1 catalyzes a structural change in
Robert Stewart, Shaunik Sharma, Timothy Wu, Sho Okuda, George Xie, Xiao Zhen Zhou, Xiao Zhen Zhou, Xiao Zhen Zhou, Xiao Zhen Zhou, Brian Shilton, Kun Ping Lu, Kun Ping Lu, Kun Ping Lu, Kun Ping Lu   +13 more
doaj   +1 more source