Results 61 to 70 of about 11,541 (227)

Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways

Journal of Hematology & Oncology, 2018
Background The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy.
Xiaolan Lian, Yu-Min Lin, Shingo Kozono, Megan K. Herbert, Xin Li, Xiaohong Yuan, Jiangrui Guo, Yafei Guo, Min Tang, Jia Lin, Yiping Huang, Bixin Wang, Chenxi Qiu, Cheng-Yu Tsai, Jane Xie, Ziang Jeff Gao, Yong Wu, Hekun Liu, Xiao Zhen Zhou, Kun Ping Lu, Yuanzhong Chen   +20 more
doaj   +1 more source

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Regulation of PRDX1 peroxidase activity by Pin1 [PDF]

Cell Cycle, 2013
Pin1 isomerizes the phosphorylated Ser/Thr-Pro peptide bonds and regulates the functions of its binding proteins by inducing conformational changes. Involvement of Pin1 in the aging process has been suggested based on the phenotype of Pin1-knockout mice and its interaction with lifespan regulator protein, p66 (Shc) .
Chu, K.L., Lew, Q.J., Rajasegaran, V., Kung, J.T., Zheng, L., Yang, Q., Shaw, R., Cheong, N., Liou, Y.-C., Chao, S.-H.   +9 more
openaire   +2 more sources

Pin1-mediated Runx2 modification is critical for skeletal development [PDF]

, 2013
Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels.
J-H Baek (13628332), JL Stein (10456334), Y-D Cho (13628326), S-C Bae (5197112), T Komori (13645591), J-Y Choi (13645606), A van Wijnen (13645594), W-J Yoon (13628329), H-M Ryoo (13628338), T Uchida (13645570), JB Lian (15884708), R Islam (9875153), K-M Woo (13628335), GS Stein (15884711)   +13 more
core  

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

Molecular Cancer, 2008
Overexpression of HER-2/Neu occurs in about 25–30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a result of erbB2 amplification, it has recently been recognized that erbB2 levels are also ...
Lu Kun, Hofstatter Erin W, Wu Bryan P, Burga Laura N, Lam Prudence B, Wulf Gerburg M   +5 more
doaj   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Pin1-mediated modification prolongs the nuclear retention of β-Catenin in Wnt3a-induced osteoblast differentiation [PDF]

, 2016
The canonical Wnt signaling pathway, in which β-catenin nuclear localization is a crucial step, plays an important role in osteoblast differentiation. Pin1, a prolyl isomerase, is also known as a key enzyme in osteogenesis.
B-S Kim (13628323), J-H Baek (13628332), R Islam (9875153), K-M Woo (13628335), T Lee (6967112), H-R Shin (13628491), Y-D Cho (13628326), H-S Bae (13628488), W-J Yoon (13628329), H-M Ryoo (13628338)   +9 more
core  

Putative role of Pin1 in herpesviral replication. [PDF]

, 2016
(A) Conserved Pin1-binding motif in lamin A/C. Amino acid sequences of the lamin A/C precursor from humans (UniProt accession number: P02545), rhesus macaques (F7GLE9), and mice (P48678) were analysed by multiple sequence alignment.
Torgils Fossen (1632481), Hanife Bahsi (3073302), Anselm H. C. Horn (440109), Heinrich Sticht (173676), Corina Hutterer (3073305), Jens Milbradt (571373), Eric Sonntag (3073311), Sabrina Wagner (3073308), Benedikt B. Kaufer (341018), Manfred Marschall (571374), Yasuko Mori (668955)   +10 more
core   +1 more source

Pin1 aggravates renal injury induced by ischemia and reperfusion in rats via Nrf2/HO-1 mediated endoplasmic reticulum stress

Acta Cirúrgica Brasileira, 2022
Purpose: To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism. Methods: By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by
Honglin Yu, Guanjun Jiang, Wei Hu, Changgeng Xu   +3 more
doaj   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source