Results 81 to 90 of about 2,931 (173)
Pin1 colocalization with phosphorylated tau in Alzheimer's disease and other tauopathies
Neurobiology of Disease, 2003 Pin1, a peptidyl-prolyl isomerase binds to mitotic serine or threonine phosphoproteins. In Alzheimer's disease (AD) evidence points to the reactivation of mitosis in vulnerable neurons.
Pankajavalli Ramakrishnan +2 more
doaj +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Salinity stress disrupts rhizosphere homoeostasis and inhibits root development. Although PGPR are known to alleviate such stress, critical knowledge gaps remain regarding the specific mechanisms by which they enhance tolerance under moderate to high salinity, particularly within the wheat rhizosphere ‐root interface.
Fuqiang Zhu +10 more
wiley +1 more source
PIN1 is a new therapeutic target of craniosynostosis [PDF]
Human Molecular Genetics, 2018 Gain-of-function mutations in fibroblast growth factor receptors (FGFRs) cause congenital skeletal anomalies, including craniosynostosis (CS), which is characterized by the premature closure of craniofacial sutures. Apert syndrome (AS) is one of the severest forms of CS, and the only treatment is surgical expansion of prematurely fused sutures in ...
Shin, H R +10 more
openaire +2 more sources
PLoS ONE, 2015 BACKGROUND:Prostate cancer initially develops in an androgen-dependent manner but, during its progression, transitions to being androgen-independent in the advanced stage. Pin1, one of the peptidyl-prolyl cis/trans isomerases, is reportedly overexpressed
Ryuhei Kanaoka +12 more
doaj +1 more source
Glia, Volume 74, Issue 8, August 2026.Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance
New Phytologist, Volume 251, Issue 3, Page 975-995, August 2026.Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap +3 more
wiley +1 more source
Pin1 targets Grb7 for proteasome-mediated degradation.
, 2016 (A) shLuc- or shPin1-infected A431 cells were treated with cycloheximide (CHX, 25 μg/ml) for the indicated times to stop protein translation. Cell lysates were collected and subjected to Western blotting with anti-Pin1, anti-Grb7, or anti-AKT antibody ...
Hsinyu Lee (149656) +9 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria +1 more
wiley +1 more source
Pin1 as a Protector of Vascular Endothelial Homeostasis [PDF]
Hypertension, 2012 To the Editor: In their recently published article in Hypertension , Chiasson and colleagues,1 in contrast to Ruan et al,2 demonstrated that binding of Pin1 to endothelial NO synthase (eNOS) facilitates the dephosphorylation and activation of the enzyme.
openaire +2 more sources
Pin1-mediated Runx2 modification is critical for skeletal development
, 2013 Runx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels.
J-H Baek (13628332) +13 more
core