Results 91 to 100 of about 11,541 (227)
The role of clathrin in post‐Golgi secretion in plant cells
New Phytologist, Volume 251, Issue 6, Page 3401-3417, September 2026.Morphology of Arabidopsis thaliana XVE»amiCHC seedlings. Summary Within the plant endomembrane system, the vesicle coat protein clathrin localizes to the plasma membrane (PM) and the trans‐Golgi Network/early endosome (TGN/EE). While the role of clathrin in endocytosis at the PM is well established, its function at TGN/EE, presumably in late secretion (
Maciek Adamowski +4 more
wiley +1 more source
Effects of Pin1 loss in HdhQ111 knock-in mice
Frontiers in Cellular Neuroscience, 2016 Huntington’s disease (HD) is a fatal, dominantly inherited, neurodegenerative disorder due to a pathological expansion of the CAG repeat in the coding region of the HTT gene.
Elena eAgostoni +21 more
doaj +1 more source
Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells. [PDF]
PLoS ONE, 2012 A peptidyl prolyl cis/trans isomerase, Pin1, regulates insulin signal transduction. Pin1 reduces responses to insulin stimulation by binding CRTC2 (CREB-regulated transcriptional co-activator 2) and PPARγ (peroxisome prolifereator- activated receptor γ),
Takafumi Uchida +7 more
doaj +1 more source
Pin1 Overexpression in Hepatocellular Carcinoma [PDF]
, 2006 By Western blotting and immunohistochemical analyses, we have demonstrated that Pin1 was overexpressed in 71.4% of hepatocellular carcinoma (HCC) and its levels correlated with the clinical survival rate. This conclusion was supported by the results from
Weng, Wei-Teng
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BNIP-H contains two Pin1-binding sites and interacts with the WW domain of Pin1. [PDF]
, 2013 Purified GST fusion proteins of Pin1 full length, Pin1 WW domain and Pin1 PPI domain were incubated with PC12 whole cell lysates containing either HA-BNIP-H full length or various BNIP-H deletions proteins, which were expressed under NGF-stimulation (A ...
Yih-Cherng Liou (28603) +4 more
core +1 more source
Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease
Frontiers in Cell and Developmental Biology, 2020 Alzheimer’s disease (AD) is the most common cause of dementia with cognitive decline. The neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles consisting of hyperphosphorylated tau and extracellular deposition of ...
Long Wang +4 more
doaj +1 more source
Glia, Volume 74, Issue 8, August 2026.Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
PLoS ONE, 2015 BACKGROUND:Prostate cancer initially develops in an androgen-dependent manner but, during its progression, transitions to being androgen-independent in the advanced stage. Pin1, one of the peptidyl-prolyl cis/trans isomerases, is reportedly overexpressed
Ryuhei Kanaoka +12 more
doaj +1 more source
Journal of Plant Nutrition and Soil Science, Volume 189, Issue 4, Page 429-444, August 2026.ABSTRACT Cadmium (Cd2+) contamination in agricultural soils has been reported to pose risks to crop productivity, food safety, and human health. This review synthesizes current knowledge on the mechanisms by which essential (S, Zn, Fe, Mg, K, Ca) and beneficial (Si, Se, rare earth elements) elements mitigate Cd2+ toxicity in plants.
Maria Manzoor, Karl Hermann Mühling
wiley +1 more source
RNAi-mediated PIN1 silencing inhibits HCC tumorigenicity [PDF]
, 2005 Background The phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 has been implicated in multiple aspects of cell cycle regulation. Our previous findings showed that PIN1 was over-expressed in more than 50% of hepatocellular carcinoma (HCC), and its ...
Pang, RWC +6 more
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