Results 91 to 100 of about 2,931 (173)

Effects of Pin1 loss in HdhQ111 knock-in mice

Frontiers in Cellular Neuroscience, 2016
Huntington’s disease (HD) is a fatal, dominantly inherited, neurodegenerative disorder due to a pathological expansion of the CAG repeat in the coding region of the HTT gene.
Elena eAgostoni, Silvia eMichelazzi, Marta eMaurutto, Alisia eCarnemolla, Yari eCiani, Yari eCiani, Paolo eVatta, Paola eRoncaglia, Paola eRoncaglia, Silvia eZucchelli, Silvia eZucchelli, Giampiero eLeanza, Fiamma eMantovani, Fiamma eMantovani, Stefano eGustincich, Stefano eGustincich, Claudio eSantoro, Silvano ePiazza, Silvano ePiazza, Giannino eDel Sal, Giannino eDel Sal, Francesca ePersichetti   +21 more
doaj   +1 more source

Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Frontiers in Cell and Developmental Biology, 2020
Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability.
Ji Hoon Yu, Chun Young Im, Sang-Hyun Min
doaj   +1 more source

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Pin1-mediated modification prolongs the nuclear retention of β-Catenin in Wnt3a-induced osteoblast differentiation

, 2016
The canonical Wnt signaling pathway, in which β-catenin nuclear localization is a crucial step, plays an important role in osteoblast differentiation. Pin1, a prolyl isomerase, is also known as a key enzyme in osteogenesis.
B-S Kim (13628323), J-H Baek (13628332), R Islam (9875153), K-M Woo (13628335), T Lee (6967112), H-R Shin (13628491), Y-D Cho (13628326), H-S Bae (13628488), W-J Yoon (13628329), H-M Ryoo (13628338)   +9 more
core  

Putative role of Pin1 in herpesviral replication.

, 2016
(A) Conserved Pin1-binding motif in lamin A/C. Amino acid sequences of the lamin A/C precursor from humans (UniProt accession number: P02545), rhesus macaques (F7GLE9), and mice (P48678) were analysed by multiple sequence alignment.
Torgils Fossen (1632481), Hanife Bahsi (3073302), Anselm H. C. Horn (440109), Heinrich Sticht (173676), Corina Hutterer (3073305), Jens Milbradt (571373), Eric Sonntag (3073311), Sabrina Wagner (3073308), Benedikt B. Kaufer (341018), Manfred Marschall (571374), Yasuko Mori (668955)   +10 more
core   +1 more source

PIN1 Provides Dynamic Control of MYC in Response to Extrinsic Signals

Frontiers in Cell and Developmental Biology, 2020
PIN1 is a phosphorylation-directed member of the peptidyl-prolyl cis/trans isomerase (PPIase) family that facilitates conformational changes in phosphorylated targets such as c-MYC (MYC).
Gabriel M. Cohn, Daniel F. Liefwalker, Ellen M. Langer, Ellen M. Langer, Rosalie C. Sears, Rosalie C. Sears, Rosalie C. Sears   +6 more
doaj   +1 more source

The vesicle trafficking R‐SNARE VAMP714 connects auxin responses, ROS and ion homeostasis in Arabidopsis under salt stress

New Phytologist, Volume 251, Issue 1, Page 207-227, July 2026.
Network of VAMP714‐dependent interactions during salt stress. Summary Plant responses to salt stress include an altered root architecture mediated by ion imbalances, reactive oxygen species (ROS) accumulation, and altered hormonal responses. Auxin is implicated in these processes.
Jialei Sun, Julien Agneessens, Jennifer F. Topping, Keith Lindsey   +3 more
wiley   +1 more source

Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis and Leaf Morphology

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4500-4527, July 2026.
ABSTRACT Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ‐specific control.
Dong An, Tiechen Shen, Shiyu Wu, Yanshen Li, Weijuan Fan, Mengxiao Yan, Yinghui Meng, Xinyi Wang, Ximing Xu, Zunfu Lv, Ling Yuan, Jun Yang, Guoquan Lu, Hongxia Wang   +13 more
wiley   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Pin1-mediated prolyl isomerization of Runx1 affects PU.1 expression in pre-monocytes

, 2014
Regulation of the hematopoietic transcription factor PU.1, a member of the ETS family, plays a critical role in the development of blood cells and in leukemia. The dosage of PU.1 has been shown to cause a shift in myelomonocytic progenitor fate.
J-H Baek (13628332), R Islam (9875153), K-M Woo (13628335), W-J Yoon (13628329), H-M Ryoo (13628338)   +4 more
core