Results 71 to 80 of about 2,931 (173)

Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo

Pharmaceutics
Background: The peptidyl–prolyl cis–trans isomerase PIN1 regulates multiple oncogenic and tumor-suppressive pathways and is frequently overexpressed in human cancers.
Yuying Ma, Yang Teng, Jinjin Liu, Yuke Deng, Lingbo Xu, Ruichen Gao, Tingyu Peng, Wei Li, Yue Wei, Linfeng Li, Zufeng Guo   +10 more
doaj   +1 more source

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source

Pin1 reduces Grb7 protein stability.

, 2016
(A) Cell lysates from shLuc- or shPin1-infected (shPin1 #1 or shPin1 #2) A431 cells were collected and subjected to Western blotting with anti-Pin1, anti-Grb7, or anti-Cyclin D1 antibody to examine the protein expression of the indicated molecules.
Hsinyu Lee (149656), Li-Hsuan Tung (3132726), Pei-Jung Lu (387014), Pei-Yu Chu (456124), Tang-Long Shen (109582), Yu-Ling Tai (149652), Ming-Yang Wang (49456), Yu-Chi Lin (762077), Wei-Pang Huang (203147), Ko-Chien Chen (3132723)   +9 more
core   +1 more source

Strigolactone‐mediated architecture regulation and stress resilience: Insights and innovations for crop breeding

Journal of Integrative Plant Biology, EarlyView.
This review summarizes the discovery, biosynthesis, and transport of strigolactone, and the D14‐D3/MAX2‐D53/SMXLs signaling module. It highlights diverse roles of strigolactone in plant architecture, stress responses, and crop breeding, including species‐specific functions, hormonal crosstalk, and agricultural applications.
Qingliang Hu, Jiayang Li, Bing Wang
wiley   +1 more source

Cellular localization of Pin1 regulates the phosphorylation status of Rb

四川大学学报. 自然科学版, 2016
Retinoblastoma tumor-suppressor proteins (Rb) plays a vital role in regulation of cell proliferation and tumor development. Recent research reveals that peptidyl-prolyl isomerase (Pin1) can regulate the function of Rb.
LIU Rui-Hong, XIE Gang, XIAO Zhi-Xiong
doaj  

Orchid genome evolution and trait innovation

Journal of Integrative Plant Biology, EarlyView.
Orchids became one of the world's most diverse plant groups through genome‐driven innovations, unique relationships with fungi and pollinators, and remarkable adaptability. This review explains the origins of orchids and the evolution of their distinctive life forms, flowers, and ecological strategies and highlights promising directions for future ...
Meng‐Yao Zeng, Cheng‐Yuan Zhou, Linying Wang, Jie Gao, Weilun Yin, Dong‐Hui Peng, Siren Lan, Feng‐Xi Yang, Zhong‐Jian Liu   +8 more
wiley   +1 more source

CryoFluorSEM – A new approach for fluorescence and EM imaging of cryofractured plant samples

Journal of Microscopy, EarlyView.
Abstract Cryo‐scanning electron microscopy (CryoSEM) permits the preparation and detailed imaging of bulky samples while keeping them in a hydrated state. For plant biology, cryofractures give information on cell ultrastructure and tissue organisation within a much larger context that is the whole organ or organism.
Raymond Wightman, Gareth Evans, Aram Gurzadyan, Ankiit Ahluwalia, Siyu Miao, Henrik Jonsson, Katharina Schiessl   +6 more
wiley   +1 more source

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2020
Alzheimer’s disease (AD) is the most common cause of dementia with cognitive decline. The neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles consisting of hyperphosphorylated tau and extracellular deposition of ...
Long Wang, Ying Zhou, Ying Zhou, Dongmei Chen, Tae Ho Lee   +4 more
doaj   +1 more source

Designed Alleles of ZmRap2.7 Decouple the Trade‐Off Between Early Flowering and Yield Penalty

Plant Biotechnology Journal, EarlyView.
ABSTRACT Flowering time genes often exhibit pleiotropic effects. In particular, early flowering is frequently associated with reduced grain yield due to a shorter growth period. This trade‐off poses a major challenge for developing early‐maturing and high‐yielding varieties, a key breeding objective in modern maize production. Here, we demonstrate that
Shumin Wang, Junjie He, Lufei Zhang, Li Guo, Ruchang Ren, Xu Han, Lishuan Wu, Huayuan Zhang, Dezhi Deng, Xiangyang Guo, Fang Yang, Chenglong Wang, Feng Tian, Yameng Liang   +13 more
wiley   +1 more source

A TAF10‐ERF109 Transcriptional Module Directs Flavonoid‐Based Stress Resilience and Yield Enhancement in Foxtail Millet and Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT To ensure sustainable agricultural production under escalating environmental constraints such as drought and salinity, innovative strategies are urgently needed. Here, we reveal in foxtail millet (Setaria italica) that transcription factors TAF10 and ERF109 form a functional complex which co‐activates the expression of key flavonoid ...
Meng Zhang, Kangwei Wang, Jiayin Fan, Yue Zheng, Qi Zhang, Haoyang Du, Shenghui Xiao, Jinguang Huang, Kang Yan, Shizhong Zhang, Qiang He, Guanqing Jia, Chengchao Zheng, Xianmin Diao, Guodong Yang, Changai Wu   +15 more
wiley   +1 more source