Results 51 to 60 of about 2,931 (173)
Journal of Hematology & Oncology, 2018 Background The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy.
Xiaolan Lian +20 more
doaj +1 more source
Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
Frontiers in Cell and Developmental Biology, 2020 The dynamic interplay between virus and host proteins is critical for establishing efficient viral replication and virus-induced pathogenesis. Phosphorylation-dependent prolyl isomerization by Pin1 provides a unique mechanism of molecular switching to ...
Mayuko Nishi +10 more
doaj +1 more source
Journal of Plant Nutrition and Soil Science, EarlyView.ABSTRACT Cadmium (Cd2+) contamination in agricultural soils has been reported to pose risks to crop productivity, food safety, and human health. This review synthesizes current knowledge on the mechanisms by which essential (S, Zn, Fe, Mg, K, Ca) and beneficial (Si, Se, rare earth elements) elements mitigate Cd2+ toxicity in plants.
Maria Manzoor, Karl Hermann Mühling
wiley +1 more source
Acta Cirúrgica Brasileira, 2022 Purpose: To investigate the role of peptidyl-prolyl cis/trans isomerase 1 (Pin1) on renal ischemia-reperfusion (I/R) injury and underlying mechanism. Methods: By establishing the in vitro and in vivo models of renal I/R, the role of Pin1 was explored by
Honglin Yu +3 more
doaj +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
, 2019 (A) 293T cells were transfected with indicated plasmids, and the amount of HA-B56α pulled-down by Flag-FAAP20 was analyzed by anti-Flag IP and WB. (B, C, D) U2OS cells were transfected with indicated plasmids, and pS113 levels of Flag-FAAP20 WT or ...
Markus Seeliger (6388112) +8 more
core +1 more source
Molecular Cancer, 2008 Overexpression of HER-2/Neu occurs in about 25–30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a result of erbB2 amplification, it has recently been recognized that erbB2 levels are also ...
Lu Kun +5 more
doaj +1 more source
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α. [PDF]
PLoS ONE, 2016 Peptidyl prolyl isomerase (PIN1) regulates the functional activity of a subset of phosphoproteins through binding to phosphorylated Ser/Thr-Pro motifs and subsequently isomerization of the phosphorylated bonds.
Hyeong-Jun Han +13 more
doaj +1 more source
The FEBS Journal, EarlyView.Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast +3 more
wiley +1 more source
Stereospecific gating of functional motions in Pin1 [PDF]
Proceedings of the National Academy of Sciences, 2011 Pin1 is a modular enzyme that accelerates the cis - trans isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regulating cell growth and neuronal survival.
Andrew T, Namanja +6 more
openaire +2 more sources