Results 51 to 60 of about 11,541 (227)
PLoS ONE, 2014 The peptidyl-prolyl isomerase Pin1 is over-expressed in several cancer tissues is a potential prognostic marker in prostate cancer, and Pin1 ablation can suppress tumorigenesis in breast and prostate cancers.
Nithya Krishnan +2 more
doaj +1 more source
Frontiers in Microbiology, 2023 IntroductionHuman parvulin peptidyl prolyl cis/trans isomerases PIN1 and PIN4 play important roles in cell cycle progression, DNA binding, protein folding and chromatin remodeling, ribosome biogenesis, and tubulin polymerization.
Umar Saeed, Zahra Zahid Piracha
doaj +1 more source
Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
Frontiers in Cell and Developmental Biology, 2020 The dynamic interplay between virus and host proteins is critical for establishing efficient viral replication and virus-induced pathogenesis. Phosphorylation-dependent prolyl isomerization by Pin1 provides a unique mechanism of molecular switching to ...
Mayuko Nishi +10 more
doaj +1 more source
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α. [PDF]
PLoS ONE, 2016 Peptidyl prolyl isomerase (PIN1) regulates the functional activity of a subset of phosphoproteins through binding to phosphorylated Ser/Thr-Pro motifs and subsequently isomerization of the phosphorylated bonds.
Hyeong-Jun Han +13 more
doaj +1 more source
Angewandte Chemie, EarlyView.Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner +5 more
wiley +1 more source
Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6 [PDF]
, 2005 The ETV6 gene is involved in many chromosomal translocations forming different fusion genes in both myeloid and lymphoid leukemias as well as in some solid tumors.
Zhang, Chang-Dong
core
Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1
Frontiers in Oncology, 2018 Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue. Pin1 is unique and only catalyzes the phosphorylated Serine/Threonine-Proline (S/
Yew Mun Lee, Yih-Cherng Liou
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner +5 more
wiley +1 more source
Pin1 targets Grb7 for proteasome-mediated degradation. [PDF]
, 2016 (A) shLuc- or shPin1-infected A431 cells were treated with cycloheximide (CHX, 25 μg/ml) for the indicated times to stop protein translation. Cell lysates were collected and subjected to Western blotting with anti-Pin1, anti-Grb7, or anti-AKT antibody ...
Hsinyu Lee (149656) +9 more
core +1 more source
The role of the master cancer regulator Pin1 in the development and treatment of cancer
Frontiers in Cell and Developmental BiologyThis review examines the complex role of Pin1 in the development and treatment of cancer. Pin1 is the only peptidyl–prolyl isomerase (PPIase) that can recognize and isomerize phosphorylated Ser/Thr-Pro peptide bonds. Pin1 catalyzes a structural change in
Robert Stewart +13 more
doaj +1 more source