Results 31 to 40 of about 2,931 (173)
Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes. [PDF]
PLoS ONE, 2016 While screening for an inhibitor of the peptidyl prolyl cis/trans isomerase, Pin1, we came across a brown algae polyphenol that blocks the differentiation of fibroblasts into adipocytes.
Atsuko Suzuki +4 more
doaj +1 more source
Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
Frontiers in Immunology, 2021 Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that can specifically recognize and isomerize the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif, change the conformation of proteins through protein phosphorylation, thus ...
Ruijie Dong +6 more
doaj +1 more source
A phosphorylated prodrug for the inhibition of Pin1 [PDF]
Bioorganic & Medicinal Chemistry Letters, 2007 Fmoc-pSer-Psi[(Z)CHC]-Pro-(2)-N-(3)-ethylaminoindole 1, showed moderate inhibition towards the mitotic regulator, Pin1 (IC(50)=28.3microM). To improve the cell permeability, the charged phosphate was masked as the bis-pivaloyloxymethyl (POM) phosphate in Fmoc-(bisPOM)-pSer-Psi[(Z)CHC]-Pro-(2)-N-(3)-ethylaminoindole 2. Antiproliferative activity towards
Song, Zhao, Felicia A, Etzkorn
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Frontiers in Pharmacology, 2018 Calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain and functions as a mediator of calcium signaling. We found that the relative activity of CaMKII was significantly lower in the WT mouse brains than in the Pin1-/- mouse ...
Taiki Shimizu +4 more
doaj +1 more source
Frontiers in Microbiology, 2023 IntroductionHuman parvulin peptidyl prolyl cis/trans isomerases PIN1 and PIN4 play important roles in cell cycle progression, DNA binding, protein folding and chromatin remodeling, ribosome biogenesis, and tubulin polymerization.
Umar Saeed, Zahra Zahid Piracha
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The regulatory role of Pin1 in neuronal death
Neural Regeneration Research, 2023 Regulated cell death predominantly involves apoptosis, autophagy, and regulated necrosis. It is vital that we understand how key regulatory signals can control the process of cell death. Pin1 is a cis-trans isomerase that catalyzes the isomerization of phosphorylated serine or threonine-proline motifs of a protein, thereby acting as a crucial molecular
Wang, Shu-Chao, Hu, Xi-Min, Xiong, Kun
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Pin1 Flips Alzheimer’s Switch [PDF]
ACS Chemical Biology, 2006 The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for Pin1 regulation of APP processing is also proposed.
openaire +2 more sources
A bibliometric analysis of PIN1 and cell death
Frontiers in Cell and Developmental Biology, 2022 Background: Regulation of cell death plays a key role in numerous diseases. As a proline isomerase, prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is important for the regulation of signaling pathways. An in-depth understanding of how Pin1 participates in the process of cell death, which affects the occurrence and development of diseases, will ...
Jia-Heng Zhang +6 more
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Pin1-KO ASC- transfected with Lentiviral Pin1 cDNA.
, 2016 Transfection was verified by observing GFP with fluorescence microscope and the western blot analysis of Pin1 and α-tubulin (1st: anti-h/m Pin1 antibody (Santa Cruz), anti-α-tubulin antibody (SIGMA), 2nd anti-mouse IgG HRP-linked antibody (Cell Signaling)
Chiyoko Uchida (230780) +4 more
core +1 more source
Phylogeny and molecular evolution analysis of PIN-FORMED 1 in angiosperm.
PLoS ONE, 2014 PIN-FORMED 1 (PIN1) is an important secondary transporter and determines the direction of intercellular auxin flow. As PIN1 performs the conserved function of auxin transport, it is expected that the sequence and structure of PIN1 is conserved. Therefore,
Pengkai Wang +8 more
doaj +1 more source