Results 111 to 120 of about 11,541 (227)

Climate change and crop resilience: harnessing metabolomics for predicting stress tolerance

New Phytologist, Volume 251, Issue 3, Page 975-995, August 2026.
Summarised methodology for metabolite biomarker discovery and genomic targets selection for those metabolites to predict high‐throughput phenotypic and agronomic traits of interest for direct uptake in breeding programmes. Summary Global warming is driving climate change to levels not experienced since the advent of agriculture, primarily due to ...
Agyeya Pratap, Arash Fazeli, Ali Bandehagh, Nicolas L. Taylor   +3 more
wiley   +1 more source

Peptidyl-prolyl cis/trans isomerase PIN1 is critical for the regulation of PKB/Akt stability and activation phosphorylation [PDF]

, 2012
[[abstract]]The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt ...
Liao, Y.;Wei, Y;Zhou, Z;Yang, J-Y;Dai, C;Chen, Y-J;Agarwal, N.K;Sarbassov, D;Shi, D;Yu, D;洪明奇;Hung, Mien-Chie
core  

Designed Alleles of ZmRap2.7 Decouple the Trade‐Off Between Early Flowering and Yield Penalty

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4966-4983, August 2026.
ABSTRACT Flowering time genes often exhibit pleiotropic effects. In particular, early flowering is frequently associated with reduced grain yield due to a shorter growth period. This trade‐off poses a major challenge for developing early‐maturing and high‐yielding varieties, a key breeding objective in modern maize production. Here, we demonstrate that
Shumin Wang, Junjie He, Lufei Zhang, Li Guo, Ruchang Ren, Xu Han, Lishuan Wu, Huayuan Zhang, Dezhi Deng, Xiangyang Guo, Fang Yang, Chenglong Wang, Feng Tian, Yameng Liang   +13 more
wiley   +1 more source

Pin1 modulates PU.1 protein stability. [PDF]

, 2012
(A) Immunoblot analysis of PU.1 protein expression in WT and Pin1-null FL-cultured bone marrow-derived DC (FLDC) and primary MEF. For FLDC, the immunoblot shown is representative of cells derived from 3 different mice.
Theresa J. Barberi (189449), Alexis Dunkle (189451), Luigi Racioppi (104562), Anthony R. Means (189453), You-Wen He (179462)   +4 more
core   +1 more source

Bacillus cereus T146 Enhances Wheat Salt Tolerance by Restructuring the Rhizosphere Microbiome and Activating TaPIN1‐Dependent Auxin Transport

Plant, Cell &Environment, Volume 49, Issue 8, Page 5703-5719, August 2026.
ABSTRACT Salinity stress disrupts rhizosphere homoeostasis and inhibits root development. Although PGPR are known to alleviate such stress, critical knowledge gaps remain regarding the specific mechanisms by which they enhance tolerance under moderate to high salinity, particularly within the wheat rhizosphere ‐root interface.
Fuqiang Zhu, Taotao Wang, Zhen Wang, Yelin Shan, Panrong Ren, Xiaomin Bie, Duojia Wang, Zheng Gao, Qingjie Guan, Lei Ge, Yuan Chen   +10 more
wiley   +1 more source

Novel Approaches for the Modulation of Pin1 Prolyl Isomerase Activity [PDF]

Pin1 is a peptidyl-prolyl isomerase that catalyses the cis-trans isomerisation of proteins at phosphorylated serine-proline and threonine-proline motifs (pS/pT-P).
Adem Ozleyen (7533248)
core   +1 more source

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Nature Communications, 2017
PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a ...
Elena Campaner, Alessandra Rustighi, Alessandro Zannini, Alberto Cristiani, Silvano Piazza, Yari Ciani, Ori Kalid, Gali Golan, Erkan Baloglu, Sharon Shacham, Barbara Valsasina, Ulisse Cucchi, Agnese Chiara Pippione, Marco Lucio Lolli, Barbara Giabbai, Paola Storici, Paolo Carloni, Giulia Rossetti, Federica Benvenuti, Ezia Bello, Maurizio D’Incalci, Elisa Cappuzzello, Antonio Rosato, Giannino Del Sal   +23 more
doaj   +1 more source

Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis

The Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY In plants, nucleotide de novo synthesis is required throughout development to provide building blocks for the synthesis of DNA, RNA and nucleotide‐derived cofactors. Inosine Monophosphate Dehydrogenases (IMPDH) are key enzymes in de novo guanylate synthesis.
Eva Dörfer, Zahra Sadeghi, Vincent Frick, Katharina Ebel, Adrian Heide, Tom Niehoff, Susanne Zehner, Lisa Fischer, Claus‐Peter Witte, Marco Herde, Torsten Möhlmann   +10 more
wiley   +1 more source

Prolyl isomerase Pin1 et la maladie d'Alzheimer [PDF]

, 2007
La maladie d'Alzheimer (MA) est une démence neurodégénérative caractérisée neuropathologiquement par une Dégénérescence Neurofibrillaire (DNF) et des dépôts amyloïdes. La DNF est constituée de protéines Tau hyper- et anormalement phosphorylées, alors que
BUEE, Luc, ANDO-ROUSSEL, Kunie
core  

PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD)

Metabolism Open, 2019
Objective: A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored. Study design: A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD.
Jing-Zhang Wang, Yu-Hua Zhang, Jing Bai, Yan-Wei Liu, Wen-Tao Du   +4 more
doaj   +1 more source