Results 111 to 120 of about 2,931 (173)
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action
Nature Communications, 2017 PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a ...
Elena Campaner +23 more
doaj +1 more source
Pin1 Overexpression in Hepatocellular Carcinoma
, 2006 By Western blotting and immunohistochemical analyses, we have demonstrated that Pin1 was overexpressed in 71.4% of hepatocellular carcinoma (HCC) and its levels correlated with the clinical survival rate. This conclusion was supported by the results from
Weng, Wei-Teng
core
BNIP-H contains two Pin1-binding sites and interacts with the WW domain of Pin1.
, 2013 Purified GST fusion proteins of Pin1 full length, Pin1 WW domain and Pin1 PPI domain were incubated with PC12 whole cell lysates containing either HA-BNIP-H full length or various BNIP-H deletions proteins, which were expressed under NGF-stimulation (A ...
Yih-Cherng Liou (28603) +4 more
core +1 more source
Ecotoxicology and Environmental SafetyExposure to fine particulate matter (PM2.5) has been increasingly associated with neurodevelopmental disorders, yet the underlying molecular mechanisms remain poorly defined. KDM5A, a histone lysine demethylase implicated in cognitive regulation, has not
Chao Song +10 more
doaj +1 more source
RNAi-mediated PIN1 silencing inhibits HCC tumorigenicity
, 2005 Background The phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 has been implicated in multiple aspects of cell cycle regulation. Our previous findings showed that PIN1 was over-expressed in more than 50% of hepatocellular carcinoma (HCC), and its ...
Pang, RWC +6 more
core
, 2014 Les modifications post-traductionnelles sont essentielles pour contrôler finement les fonctions cellulaires des protéines. Un mécanisme peu connu, la peptidyl-prolyl cis-trans isomérisation, joue également un rôle dans la régulation des protéines.
Justine Marsolier +3 more
core +1 more source
Research progress of the impact of Pin1 on the pathogenesis of Alzheimer's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Peptidyl-prolyl cis/trans isomerase (Pin1) has been identified as an important factor that can affect many neurodegenerative diseases as well as neoplasms.
Wei LI, Shi-fu XIAO
doaj
, 2012 [[abstract]]The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt ...
Liao, Y.;Wei, Y;Zhou, Z;Yang, J-Y;Dai, C;Chen, Y-J;Agarwal, N.K;Sarbassov, D;Shi, D;Yu, D;洪明奇;Hung, Mien-Chie
core
Pin1 modulates PU.1 protein stability.
, 2012 (A) Immunoblot analysis of PU.1 protein expression in WT and Pin1-null FL-cultured bone marrow-derived DC (FLDC) and primary MEF. For FLDC, the immunoblot shown is representative of cells derived from 3 different mice.
Theresa J. Barberi (189449) +4 more
core +1 more source
Novel Approaches for the Modulation of Pin1 Prolyl Isomerase Activity
Pin1 is a peptidyl-prolyl isomerase that catalyses the cis-trans isomerisation of proteins at phosphorylated serine-proline and threonine-proline motifs (pS/pT-P).
Adem Ozleyen (7533248)
core +1 more source