Results 131 to 140 of about 11,541 (227)

Identification and inhibition of PIN1-NRF2 protein–protein interactions through computational and biophysical approaches

Scientific Reports
NRF2 is a transcription factor responsible for coordinating the expression of over a thousand cytoprotective genes. Although NRF2 is constitutively expressed, its stability is modulated by the redox-sensitive protein KEAP1 and other conditional binding ...
Adem Ozleyen, Gizem Nur Duran, Serhat Donmez, Mehmet Ozbil, Richard G. Doveston, Tugba Boyunegmez Tumer   +5 more
doaj   +1 more source

Макроциклічні інгібітори PIN1

, 2022
В даній роботі були проаналізовані відомі інгібітори, їх переваги і недоліки, а також синтезовано нові макроциклічні інгібітори PIN1 для майбутніх досліджень активації світлом. Ізомер, що генерується видимим світлом демонструє набагато сильнішу токсичність проти пухлинних клітин, ніж ізомер, що утворюється під ультрафіолетом.
openaire   +1 more source

파골세포와 근육세포의 세포 융합 과정에서의 Pin1 의 역할 [PDF]

, 2015
학위논문 (박사)-- 서울대학교 대학원 : 치의과학과, 2015. 2. 류현모.Cell-cell fusion is critical for the conception, development, and physiology of multicellular organisms. Although cellular fusogenic proteins and the actin cytoskeleton are implicated in cell-cell fusion, it ...
이슬람라비아
core  

Pin1, the master orchestrator of bone cell differentiation [PDF]

, 2017
Pin1 is an enzyme that specifically recognizes the peptide bond between phosphorylated serine or threonine (pS/pT-P) and proline. This recognition causes a conformational change of its substrate, which further regulates downstream signaling. Pin1−/− mice
R Islam (9875153), W-J Yoon (13628329), H-M Ryoo (13628338)   +2 more
core  

PIN1 Gene [PDF]

, 2020
openaire   +1 more source

Proline-directed phosphorylation and prolyl isomerization oppose each other to regulate PSD-95 ubiquitination and excitatory synaptic plasticity. [PDF]

Front Mol Neurosci
Kurup P, Thielbar AR, Jasinski E, Galvan B, Singh T, Kanuru S, Gor HT, Von Rommel A, Parungao MR, Parada DBP, Patel MJ, Delgado JY.   +11 more
europepmc   +1 more source

A Personalized Therapeutic Approach for Liver Cancers Expressing the African-Centric P47S Variant of TP53. [PDF]

Mol Cancer Res
Foster M, Casey K, Cassel J, Ye Y, Diaz J, Shuda McGuire K, Barnoud T, Murphy ME.   +7 more
europepmc   +1 more source

Mapping Phosphorylation-Specific Pin1-CRMP2 Interactions Using an Integrated Mass Spectrometry Approach. [PDF]

ACS Chem Biol
Kay DF, Brooks NJ, Caulton SG, Jayasekera HS, Lovering AL, Leney AC.   +5 more
europepmc   +1 more source

Self-synergizing mutual prodrug liposomes for targeted cancer therapy <i>via</i> redox-amplified Pin1 inhibition. [PDF]

Theranostics
Kim N, Kim I, Jo H, Song N, Jo S, Lee S, Kim H, Lim C, Lee D.   +8 more
europepmc   +1 more source

Theaflavin-3,3'-Digallate Targets Pin1 to Suppress Hepatocellular Carcinoma Malignant Proliferation Through Modulation of MAPK and PI3K/AKT Signaling Pathways In Vitro. [PDF]

Biomolecules
Lv S, Jiang W, Liu J, Tao J, Zhong H, He H, Liao X, Xie J, Ouyang X, Wang W.   +9 more
europepmc   +1 more source