Results 141 to 150 of about 2,931 (173)

PtdIns5P and Pin1 in oxidative stress signaling

Advances in Biological Regulation, 2013
Oxidative signaling is important in cellular health, involved in aging and contributes to the development of several diseases such as cancer, neurodegeneration and diabetes. Correct management of reactive oxygen species (ROS) prevents oxidative stress within cells and is imperative for cellular wellbeing.
Keune, Willem Jan, Jones, David R., Divecha, Nullin   +2 more
openaire   +3 more sources

Regulation of Microtubule Assembly by Tau and not by Pin1

Journal of Molecular Biology, 2016
The molecular mechanism by which the microtubule-associated protein (MAP) tau regulates the formation of microtubules (MTs) is poorly understood. The activity of tau is controlled via phosphorylation at specific Ser/Thr sites. Of those phosphorylation sites, 17 precede a proline, making them potential recognition sites for the peptidyl-prolyl isomerase
Steffen Kutter, Timo Eichner, Alexandra M. Deaconescu, Dorothee Kern   +3 more
openaire   +3 more sources

The Significance of Pin1 in the Development of Alzheimer's Disease

Journal of Alzheimer's Disease, 2007
Pin1 protein, a peptidyl-prolyl cis-trans isomerase plays an important regulatory role in neuronal function. Recent studies indicate that Pin1 may promote the dephosphorylation of tau and restore its ability to bind to and polymerize microtubles. Previous studies on postmortem human brains showed that Pin1 is down-regulated in advanced Alzheimer's ...
Suqing, Wang, Brook P, Simon, David A, Bennett, Julie A, Schneider, James S, Malter, Deng-Shun, Wang   +5 more
openaire   +2 more sources

Pin1: Inhibitors and Mechanism

2010
Introduction Peptidyl-prolyl isomerase (PPIase) enzymes are something of an enigma. Part chaperone, part enzyme, they play multiple roles in multiple biological systems. Cyclophilin and FKBP were first discovered in the late 1980’s because they bind to distinct natural products, cyclosporine and FK506 respectively, immunosuppressants which act as ...
Felicia A. Etzkorn, Joseph P. Noel, Yan Zhang, Xiaodong J. Wang   +3 more
openaire   +1 more source

Pin1

AfCS-Nature Molecule Pages, 2010
Tae Ho Lee, Xiao Zhen Zhou, Kun Ping Lu
openaire   +1 more source

Pin1 in Alzheimer's disease.

Journal of neurochemistry, 2006
Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of beta-amyloid (Abeta) peptides and neurofibrillary tangles, respectively. These observations suggest that phosphorylation events are
D Allan, Butterfield, Hafiz Mohmmad, Abdul, Wycliffe, Opii, Shelley F, Newman, Gururaj, Joshi, Mubeen Ahmad, Ansari, Rukhsana, Sultana   +6 more
openaire   +1 more source

Expression and significance of pin1 in the wound healing

Archives of Dermatological Research
The aim of this study is to delineate the expression patterns of prolyl cis-trans isomerase NIMA-interacting protein 1 (Pin1), Glial cell-derived neurotrophic factor (GDNF), and Angiotensin II (ANG II) during the process of wound repair, and to ascertain the effects of Pin1, GDNF, and ANG II on the healing of wounds in a rat model.
Qing-Xian, Ren, Qian-Shu, Zhuang, Guo-Liang, Shen   +2 more
openaire   +2 more sources

Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

Cell, 2021
Kazuhiro Koikawa, Shin Kibe, Futoshi Suizu   +2 more
exaly  

Cobalt induces neurodegenerative damages through Pin1 inactivation in mice and human neuroglioma cells

Journal of Hazardous Materials, 2021
Fuli Zheng, Chunyan Zheng, Yuan-Liang Wang   +2 more
exaly  

Pin1

2017
Dana Onica, David W. Litchfield
openaire   +1 more source