Results 101 to 110 of about 2,931 (173)
PIN1 gene variants in Alzheimer's disease
, 2009 Background Peptidyl-prolyl isomerase, NIMA-interacting 1 (PIN1) plays a significant role in the brain and is implicated in numerous cellular processes related to Alzheimer's disease (AD) and other neurodegenerative conditions.
Berdynski, Mariusz +38 more
core +1 more source
Blood-testis barrier integrity depends on Pin1 expression in Sertoli cells
Scientific Reports, 2017 The conformation and function of a subset of serine and threonine-phosphorylated proteins are regulated by the prolyl isomerase Pin1 through isomerization of phosphorylated Ser/Thr-Pro bonds. Pin1 is intensely expressed in Sertoli cells, but its function
Rabia Islam +10 more
doaj +1 more source
Therapeutic Advances in Medical Oncology, 2020 Background: Triple negative breast cancer (TNBC) is the subset of breast cancer associated with the poorest outcome, and currently lacks targeted treatments.
Catherine Knowlson +5 more
doaj +1 more source
, 2011 MEF2 (myocyte enhancer factor 2) transcription factors (MEF2A-D) are highly expressed in skeletal muscle cells, they bind to a conserved AT rich DNA sequence through their N-ter MADS and MEF2 domains and activate transcription via their C-ter ...
MAGLI, Alessandro +7 more
core
Pin1 Deficiency Causes Endothelial Dysfunction and Hypertension
, 2011 Pin1 is a peptidyl prolyl cis-trans isomerase that only binds to and isomerizes phosphorylated serine/threonine-proline motifs, inducing conformational changes that alter target protein function and phosphorylation ...
Piyali Chatterjee +4 more
core +1 more source
PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD)
Metabolism Open, 2019 Objective: A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored. Study design: A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD.
Jing-Zhang Wang +4 more
doaj +1 more source
PIN1 expression contributes to hepatic carcinogenesis
, 2006 The phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 is over-expressed in more than 50% of hepatocellular carcinomas (HCCs). To investigate its potential oncogenicity, we over-expressed PIN1 in a non-transformed human liver cell line MIHA.
Lee, TK +6 more
core +1 more source
Pin1 promotes GR transactivation by enhancing recruitment to target genes [PDF]
, 2013 The glucocorticoid receptor (GR) is a ligand activated transcription factor, serving to regulate both energy metabolism and immune functions. Factors that influence cellular sensitivity to glucocorticoids (GC) are therefore of great interest.
Matthews, L +14 more
core +1 more source
Overexpression of PIN1 in EBV-associated NPC.
, 2016 (A) IHC staining was used to illustrate the overexpression of PIN1 in representative NPC primary tumors (NPC1-NPC4). All of the cases were EBV-positive undifferentiated carcinomas. NPC1, NPC3 and NPC4 are from the patients with stage 3 disease.
Siu-Tim Cheung (775397) +5 more
core +1 more source
Pulmonary CirculationChronic thromboembolic pulmonary hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE), yet its underlying mechanisms remain poorly understood.
Lynn Willems +11 more
doaj +1 more source