Results 61 to 70 of about 113,405 (290)

Despojos y formas de agenciar futuro en América Latina

open access: yesRevista Controversia
La elaboración de este dossier para el número 223 de la revista concatenó diversas controversias y particularidades, producto de la confluencia de nutridos debates interdisciplinarios. El mismo nombre de la revista nos invitaba a considerar un horizonte
Anderson Villa Beltrán   +2 more
doaj   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

open access: yesAdvanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel   +10 more
wiley   +1 more source

A study on the optimal PPP model for transport: the case of road and rail in South Korea

open access: yes, 2013
In recent decades the Public Private Partnership (PPP) has been widely regarded as an innovative way to construct transport infrastructures and to improve the quality of service.
Gil, Byungwoo
core   +1 more source

Análise do GNSS PPP multi-constelações com uso dos sistemas GPS, GLONASS e Galileo

open access: yesRevista Brasileira de Cartografia, 2020
Dentre os sistemas que compõem o GNSS, estão completamente funcionais o GPS e o GLONASS. Além disso, encontram-se em desenvolvimento o Galileo e o BeiDou, sendo que o Galileo dispõe de 17 satélites operantes.
Raiane Rintielle Vaz Menezes   +1 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai   +12 more
wiley   +1 more source

NAVIGATING THE RISKS OF PUBLIC- PRIVATE PARTNERSHIPS: CHALLENGES AND MITIGATION STRATEGIES [PDF]

open access: yesEastern European Journal of Regional Studies
This study explores the obstacles and risks that Public-Private Partnerships (PPPs) encounter in carrying out economic development initiatives, across Romanian nations.
Elena BIZIM (SURDU)
doaj   +1 more source

Public–Private Partnership in Health Care: A Comparative Cross-sectional Study of Perceived Quality of Care Among Parents of Children Admitted in Two Government District-hospitals, Southern India [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2016
Introduction: Perceived better quality of care draws lower socioeconomic classes of Indians to more expensive private setups, leading to poverty illness poverty cycle.
B. Shantaram Baliga   +4 more
doaj   +1 more source

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

open access: yesAdvanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma   +8 more
wiley   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

open access: yesAdvanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka   +10 more
wiley   +1 more source

Are PPP Tests Erratically Behaved? Some Panel Evidence [PDF]

open access: yes
This paper examines whether, in addition to standard unit root and cointegration tests, panel approaches also produce test statistics behaving erratically when applied to tests for PPP.
Hanck, Christoph   +1 more
core  

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