Results 31 to 40 of about 2,400 (174)
The FEBS Journal, EarlyView.Insoluble protein aggregates are a hallmark of neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). The ubiquitin–proteasome system (UPS) serves as a neuroprotective quality control mechanism that clears aggregates. PML nuclear bodies (NBs) were proposed to serve as hubs for SUMO‐primed ubiquitylation and degradation of misfolded ...
Tabea Stark, Stefan Müller
wiley +1 more source
A survey of post-quantum cryptographic chips: Current status, challenges, and future directions
Security and SafetyThe development of quantum computing poses a serious threat to traditional cryptographic systems and has driven the rapid development of post-quantum cryptography (PQC).
Zhu Yihong, Liu Leibo
doaj +1 more source
Conserved and Unique Roles of Chaperone-Dependent E3 Ubiquitin Ligase CHIP in Plants
Frontiers in Plant Science, 2021 Protein quality control (PQC) is essential for maintaining cellular homeostasis by reducing protein misfolding and aggregation. Major PQC mechanisms include protein refolding assisted by molecular chaperones and the degradation of misfolded and ...
Yan Zhang, Gengshou Xia, Qianggen Zhu
doaj +1 more source
Combating ageing beyond the cell: Emerging roles of extracellular proteostasis
The FEBS Journal, EarlyView.Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh +7 more
wiley +1 more source
The FEBS Journal, EarlyView.This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley +1 more source
The role of RNF149 in the pre-emptive quality control substrate ubiquitination
Communications Biology, 2023 E3 ligase RNF149 contributes to the pre-emptive quality control (pQC) pathway & interacts with AIRAPL in a ubiquitin-dependent manner, with loss of RNF149 function appearing to increase the translocation flux of pQC substrates to the ER.
Aster Legesse +6 more
doaj +1 more source
The effect of photodynamic therapy in head and neck cancer: A comprehensive review of in vivo models
Photochemistry and Photobiology, EarlyView.This review evaluates Photodynamic Therapy (PDT) in in vivo head and neck cancer models. PDT effectively generates ROS, reducing tumor growth, cell proliferation and angiogenesis while enhancing survival and immune responses. However, methodological heterogeneity highlights the urgent need for standardized dosimetric protocols to ensure reproducibility
Bibiana Padilha de Menezes da Silva +5 more
wiley +1 more source
Toque sua pele?: Desafiando novas ações para detecção da hanseníase
Hansenologia Internationalis, 2008 .
Rosemari Baccarelli
doaj
A Practical Implementation of Post-Quantum Cryptography for Secure Wireless Communication
NetworkRecent advances in quantum computing have prompted urgent consideration of the migration of classical cryptographic systems to post-quantum alternatives.
Babatunde Ojetunde +4 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 15, 15 August 2026.Systolic overload increases the synthesis of cardiac proteins, both misfolded and native, leading to cardiac hypertrophy and elevated proteostasis burden. Meanwhile, systolic overload also increases Ser14‐RPN6 phosphorylation (pS14‐RPN6), thereby increasing proteasome (Psm) proteolytic capacity and meeting the increased demand for protein degradation ...
Md. Salim Ahammed +7 more
wiley +1 more source