Results 41 to 50 of about 1,374,744 (197)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

TALN et IHM : une approche transdisciplinaire pour la saisie de textes de personnes en situation de handicaps [PDF]

open access: yes, 2015
International audienceCe papier vise d'une part, à présenter une synthèse des méthodes d'optimisation pluridisciplinaires alliant le traitement automatique de la langue naturelle et celui l'interaction homme-machine et d'autre part à soulever les ...
BOISSIÈRE, Philippe   +4 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

La Plateforme de Communication Alternative : Un système d'aide à la communication pour personnes handicapées

open access: yes, 2004
L'aide à la communication pour personnes handicapées doit prendre en compte les besoins des utilisateurs en général, mais également pouvoir s'adapter aux diverses situations de communication rencontrées au quotidien par l'utilisateur et à l'évolution ...
Bellengier, Emmanuel   +2 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

A probabilistic high cycle fatigue model applied to cast Al-Si alloys [PDF]

open access: yes, 2013
In this work, the high cycle fatigue behavior of cast hypo-eutectic Al-Si alloys is investigated. It is observed that two different coexisting fatigue initiation mechanisms can occur in these materials depending on the presence of different ...
AUGUSTINS, Louis   +3 more
core   +3 more sources

La carrière criminelle : définition et prédiction [PDF]

open access: yes, 1986
The concept of a criminal «career» is being used more and more in the recent criminological literature. This article analyzes the pertinence of explaining this concept by its specific components.
LeBlanc, Marc
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Fast and Slow Speech Rate: a Characterisation for French [PDF]

open access: yes, 1998
This paper is concerned with the evaluation of speech rate in French. Usually, this dynamic parameter is described as a unidimensional quantitative dimension.
Zellner, Brigitte
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

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