Results 131 to 140 of about 2,548,600 (297)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Enquête transversale sur la prévalence des maladies chroniques et des facteurs associés à un mauvais pronostic chez les patients COVID-19: cas du Centre Hospitalier Al Farabi au Nord-Est marocain

, 2023
Saliha Mharchi, A. Mâamri
openalex   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Mortalité périnatale dans la Zone de Santé de Ngaba, Kinshasa, République Démocratique du Congo : Prévalence et facteurs de risque

Revue Congolaise des Sciences et Technologies
La mortalité périnatale reste un problème de santé publique en République Démocratique du Congo en général et dans la zone de santé de Ngaba en particulier.
Alex Kiomba Mbo , Bertin Mukuna Nyembo , Félicien Tshimungu Kandolo   +2 more
doaj   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Pratique de la sédation palliative à l'unité de médecine palliative du CHUV : bilan à trois ans : une étude rétrospective. [PDF]

, 2015
Introduction : La sédation palliative (SP) est un acte médical de dernier recours visant à soulager la souffrance intolérable causée par des symptômes réfractaires des patients en fin de vie.
HOCHART, E.
core  

Note de synthèse - Prévalence et coûts financiers des maladies cognitives au Canada : un rapport de la Société Alzheimer du Canada (2016) [PDF]

, 2016
Société Alzheimer du Canada
openalex   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

La face cachée des difficultés d’apprentissage au collège [PDF]

, 2016
Nous savons que de plus en plus d’étudiants arrivent au collège avec un diagnostic de trouble d’apprentissage : dyslexie, dysorthographie, dysgraphie, dyscalculie, trouble déficitaire de l’attention avec ou sans hyperactivité, etc.
Cabot, Isabelle
core