Results 81 to 90 of about 2,290,098 (252)
Costs and Benefits of Preventing Workplace Accidents: The Case of Participatory Ergonomics [PDF]
This paper provides a cost-benefit analysis of a participatory ergonomics program conducted at the beginning of the 1990s to reduce back-related disorders among packers at a warehouse of the Société des Alcools du Québec in Quebec City.
Paul Lanoie, Sophie Tavenas
core
Pour une prévention en "actes": En conclusion [PDF]
, 2002 National audienceConfrontée à ce système d’influence à multifacettes, la prévention des conduites dopantes appelle le développement d’une stratégie de prévention portée par les différents acteurs du mouvement sportif car ce qui frappe l’observateur, c ...
Guy, Daniel
core +1 more source
Réflexion sur les possibilités et les limites de la prévention du VIH auprès des hommes ayant des relations sexuelles avec d’autres hommes dans les sociétés différenciées [PDF]
, 2006 Les discours sur la prévention oscillent souvent entre les pôles du contrôle social et du désistement de l’État-providence. Ces deux discours proposent des visions de la place de l’État dans la prévention des problèmes sociaux qui semblent démenties par ...
Blais, Martin
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Criminologie, 2018 Nous proposons d’analyser les développements jurisprudentiels de la Cour européenne en matière de prévention du suicide en prison et dans les commissariats de police et leurs effets paradoxaux sur les politiques de prévention conduites par les États ...
Gaëtan Cliquennois
doaj +1 more source
L’efficacité des programmes de prévention de la toxicomanie axés sur les familles [PDF]
, 1998 Cette recension des écrits examine l'efficacité de programmes de prévention des toxicomanies auprès des familles. De nombreux travaux soulignent le rôle déterminant des familles dans la transmission des habitudes de consommation. De plus, selon plusieurs
Dufour, Magali H., Nadeau, Louise
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source