Results 91 to 100 of about 2,327,140 (248)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Occupational Health Problem Network : the Exposome

, 2008
We present a thinking on the concept of relational networks applied to the french national occupational disease surveillance and prevention network (R\'eseau National de Vigilance et de Pr\'evention des Pathologies Professionnelles, RNV3P). This approach
Bicout, Dominique J, De Gaudemaris, Régis, Faisandier, Laurie   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Anticipation et rapidité sont la base d'une gestion efficace

Sciences, Eaux & Territoires, 2012
Lorsqu'une espèce exotique envahissante a débuté son extension dans sa région d'accueil, il est souvent impossible de l'éradiquer. Même son confinement et la limitation de ses effectifs restent des opérations excessivement compliquées, coûteuses et ...
I. MANDON-DALGER, G. FRIED, P. EHRET, N. POULET, E. MAZAUBERT, A. DUTARTRE   +5 more
doaj   +1 more source

Intervenants en toxicomanie et prévention de la transmission sexuelle du VIH [PDF]

, 2000
L'étude a développé deux axes de recherche: dans le premier, elle a visé à connaître comment les intervenants en toxicomanie appréhendent leurs tâches de prévention de la transmission sexuelle du VIH/sida (PST), quels sont les problèmes qu'ils ...
Coda, Paola, Gervasoni, Jean-Pierre, Moreau-Gruet, Florence   +2 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

L’Algerie: une region mediterraneene tres sensible aux incendies de foret

Territorium: Revista Portuguesa de riscos, prevenção e segurança, 2017
Comme dans de nombreux pays de la Méditerranée, les zones boisées en Algérie sont soumises à un risque récurrent des incendies de forêt qui est favorisée par l'extrême inflammabilité des espèces forestières méditerranéennes durant l'été. Ce travail tente
Souidi Zahira, Benbakar Hadj
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Risk-sharing policies in the context of the French Flood Prevention Action Programmes [PDF]

This article analyzes the consequences for risk distribution of the French Flood Prevention Action Programme (PAPI). By redirecting floods from the most vulnerable to the least vulnerable areas, PAPIs expose farmers to greater flood risks.
Enjolras, Geoffroy, Erdlenbruch, Katrin, Grelot, Frédéric, Kast, Robert, Thoyer, Sophie   +4 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source