Results 91 to 100 of about 2,428,341 (233)
Ce qui freine la prévention des cancers
https://sms.hypotheses.org/59525La prévention en santé désigne l’ensemble des actions mises en place pour éviter l’apparition de maladies, les détecter tôt ou limiter leurs conséquences.
Sampic, Maureen
core +4 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2017 L’enjeu est de s’interroger sur la prévention de la radicalisation – et d’autres formes d’emprises –, notamment en soutenant les métissages ...
mission métropolitaine de prévention des toxicomanies et des conduites à risques du département de Seine-Saint-Denis et de la vi +1 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Le principe de précaution comme norme de l'action publique ou la proportionnalité en question [PDF]
L'introduction du principe de précaution en France a donné naissance à deux conceptions antagonistes. La première, correspondant à la définition légale et à la doctrine européenne, promeut une prévention précoce mais proportionnée de risques potentiels ...
Olivier Godard
core
Prévention des IST : état des lieux des politiques de prévention et rôle du pharmacien d’officine
, 2021 Les infections sexuellement transmissibles sont un problème de santé publique. A ce titre, la prévention des IST n’en est que plus nécessaire. Les moyens de prévention des IST sont nombreux et le gouvernement œuvre en ce sens : stratégie nationale de ...
Marchal, Chloé
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
International audienceThe status of temporary worker is unique. It involves a three-way relationship between an employee, an employer, and a user. Accidents are particularly prevalent for this type of employment and are slow to decrease.
Langard, Benoit, Schweitzer, Jean-Michel
core +2 more sources
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source