Results 111 to 120 of about 2,428,341 (233)

Prise en compte de la sécurité dès la conception du produit, expérience pédagogique. [PDF]

open access: yes, 2012
La démarche de « Prévention intégrée» consiste à appliquer au plus tôt des principes de conception sûre en termes de sécurité des opérateurs d’équipements de travail.
MARSOT, Jacques   +6 more
core  

Geographical risks in the touristic region of Tusnad-Balvanyos [PDF]

open access: yesCinq Continents, 2011
Des risques géographiques dans la zone touristique Tușnad-Balvanyos. Les régions volcaniques représentent un élément d’intérêt majeur tant pour les spécialistes, du point de vue de l’étude de diverses caractéristiques, que pour les touristes qui ...
ANA-MARIA TALOS
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Innovation en métrologie pour agir en prévention primaire

open access: yes
International audienceIntroductionLes nouvelles exigences introduites pour les services de prévention et de santé au travail, notamment la réalisation d’une action de prévention primaire tous les 4 ans pour chaque entreprise et la mise à jour des fiches ...
Ngo, Vinh   +8 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prévenir ou guérir ? De la prévention médicale à la prévention judiciaire

open access: yes, 2007
Le Ninivin Dominique. Prévenir ou guérir ? De la prévention médicale à la prévention judiciaire. In: Revue juridique de l'Ouest, 2007-3. pp.
Le Ninivin, Dominique
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

La prévention

open access: yes, 2005
Curtet Francis. La prévention. In: Raison présente, n°153, 1er trimestre 2005. De la drogue et des drogues. pp.
Curtet, Francis
core   +1 more source

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