Evaluation des activités de prévention du VIH/sida dans le canton de Genève, 2005 [PDF]
, 2006 La Direction générale de la santé du canton de Genève (DGS) a conclu des partenariats avec les associations et institutions suivantes pour la période 2005-2007: 1. Groupe sida Genève (GSG), Antenne de l'Aide Suisse contre le Sida (ASS) 2.
Balthasar, Hugues +3 more
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Le tourisme sexuel en Thaïlande : une prostitution entre misère et mondialisation
Téoros, 2003 Près de neuf millions de touristes ont visité la Thaïlande en l’an 2000, parmi lesquels 65 à 70 % sont des hommes. Malgré d’intenses campagnes médiatiques de sensibilisation contre le tourisme sexuel et nombre de batailles judiciaires à l’encontre des ...
Franck Michel
doaj
La prévention du tabagisme et les facteurs organisationnels en médecine générale: une étude pilote en Suisse romande [PDF]
, 2014 Context: Several studies have been carried out to describe how general practitioners (GPs) follow smoking cessation counseling's recommendations and to identify GP-related factors that influence their practice.
ANDREY, S.
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Social Construction of the Audit Expectation Gap: The Market of Excuses [PDF]
Nous examinons dans cet article l'“audit expectation gap” en nous appuyant sur l'étude de l'évolution des objectifs de l'audit dans le contexte français.
Chrystelle Richard, Imen Jedidi
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La prévention infirmière du syndrome de sevrage alcoolique et de l'état confusionnel aigu: revue de la littérature [PDF]
, 2017 Contexte : Cette revue de la littérature porte sur le syndrome de sevrage alcoolique et le délirium tremens, autrement nommé état confusionnel aigu.
Darbellay, Karen, Salamat, Aziz
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Costs and Benefits of Preventing Workplace Accidents: The Case of Participatory Ergonomics [PDF]
This paper provides a cost-benefit analysis of a participatory ergonomics program conducted at the beginning of the 1990s to reduce back-related disorders among packers at a warehouse of the Société des Alcools du Québec in Quebec City.
Paul Lanoie, Sophie Tavenas
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