Results 121 to 130 of about 2,300,230 (246)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Le tourisme sexuel en Thaïlande : une prostitution entre misère et mondialisation
Téoros, 2003 Près de neuf millions de touristes ont visité la Thaïlande en l’an 2000, parmi lesquels 65 à 70 % sont des hommes. Malgré d’intenses campagnes médiatiques de sensibilisation contre le tourisme sexuel et nombre de batailles judiciaires à l’encontre des ...
Franck Michel
doaj
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
La prévention dans la transition épidémiologique
, 2013 Sous le titre qui peut sembler un peu abscons « La prévention dans la transition épidémiologique », l’exposé qui suit se propose de revisiter ce qu’on appelle la transition épidémiologique sous le prisme de la prévention ; il s’agit de voir comment les ...
Leridon, Henri
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2022 Nous nous sommes intéressées à identifier les actions de prévention primaire, secondaire et tertiaire qui pourraient être coordonnées, ainsi qu’à définir ce que représente la prévention intégrée visant la coordination de ces actions de prévention en ...
Calvet, Bénédicte
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Risques de mort, paroles de vie (vol. 21)
, 1997 L'ouvrage rend compte d'une enquête qualitative auprès de personnes ayant survécu à une overdose de stupéfiants orientée vers la mise en place de mesures visant à limiter le nombre et les conséquences parfois mortelle de ces accidents.
Gazareth, Pascale
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source