Results 51 to 60 of about 5,580,867 (303)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin +2 more
wiley +1 more source
Semi-passivity and practical stability for switched discrete-time nonlinear systems
Franklin Open, 2023 This paper concerns semi-passivity and practical stability of a switched discrete-time nonlinear system. First, semi-passivity concept is proposed to achieve broader application.
Hongbo Pang, Shuo Liu, Chensong Li
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
, 2015 Practical Action Southern Africa is working in partnership with five development organisations in five districts in the semi-arid areas of Zimbabwe to enhance food security and livelihood options of the people. The project is being implemented in five of
Practical Action Zimbabwe
core +5 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Stability of Groups with Costly Beliefs and Practices [PDF]
Journal of Artificial Societies and Social Simulation, 2011 Costly signaling theory has been employed to explain the persistence of costly displays in a wide array of species, including humans. Henrich (2009) builds on earlier signaling models to develop a cultural evolutionary model of costly displays. Significantly, Henrich's model shows that there can be a stable equilibrium for an entire population ...
Wesley J. Wildman, Richard Sosis
openaire +2 more sources
Computation Model of Cyber-Physical Immunosensor System
IEEE Access, 2019 This paper initiates a study toward developing and applying computation models of cyber-physical immunosensor systems (CPISS). The focus is on the mathematical description of continuous population dynamics combined with dynamic logic used for discrete ...
Vasyl Martsenyuk +1 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source